(A) Stained, diploid spread of chicken metaphase chromosomes. (B) Same spread after multicolor FISH with pseudocolored chromosomes. (C) Probes were detected using antibodies. (D) Mid-plane light optical section through a chicken fibroblast nucleus shows mutually exclusive chromosome territories with homologous chromosomes seen in separate locations.
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Chromosomes occupy specific regions of a nucleus, called "chromosome territories." These subdomains might be doing much more than just keeping everything organized.
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