Centromere structure and organization.
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Centromere structure and organization.
(A) Centromeric chromatin underlies the kinetochore, which contains inner and outer plates that form microtubule-attachment sites. Pericentromeric heterochromatin flanks centromeric chromatin, and contains a high density of cohesin, which mediates sister-chromatid cohesion. (B) Schematic depiction of centromeric DNA in humans and mice, Drosophila, Schizosaccharomyces pombe, Candida albicans, and Saccharomyces cerevisiae.
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Transcriptionally inactive heterochromatin is vital to sustaining stable chromosome structure throughout the cell cycle. See how heterochromatin formation depends on RNA interference.
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