CDKs are the priming kinases for Plk1.
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CDKs are the priming kinases for Plk1.
(A) shows a general model. In the absence of a bound substrate, Plk1 is inactive due to the intramolecular interactions. To bind Plk1, the substrate must be primed by another kinase like CDKs. Once phosphorylated, the substrate binds to Plk1 and releases the self-inhibited Plk1. Active Plk1 subsequently phosphorylates the substrate at more sites. (B) gives a specific example. During mitosis, CDK1, Plk1 and Nedd1 co-localize at the centrosome where CDK1 and Plk1 sequentially phosphorylate Nedd1.
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What regulates protein kinase activity during cell division? Interestingly, protein kinases phosphorylate each other as well as act on common targets.
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