Axon tracing of RGC projection into the superior colliculus
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Axon tracing of RGC projection into the superior colliculus
DiI was injected into a small spot of the retina in both wild-type and ephrin-B mutant mice, and RGC axons were traced into the superior colliculus. Whereas projections with the wild-type mouse are grouped together into a compact zone (left; red halo), in the ephrin-B mutant, there are multiple termination zones, indicating incorrect axon guidance in the superior colliculus.
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Cell-cell signaling is critical during the proper development of the nervous system. Learn how Eph receptors and their ligands, the ephrins, control neural connections.
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