During the cell cycle, the activation of Plk1 relies on the phosphorylation at T210 within the activation segment, which is performed by another kinase Aurora A. This process requires a cofactor Bora, which may induce Plk1 into a conformation that is easier for Aurora A to approach. The way Bora binds Plk1 fits the classical model as Bora needs to be primed itself by CDK1 phosphorylation.
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