Aurora A together with Bora activates Plk1
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Aurora A together with Bora activates Plk1
During the cell cycle, the activation of Plk1 relies on the phosphorylation at T210 within the activation segment, which is performed by another kinase Aurora A. This process requires a cofactor Bora, which may induce Plk1 into a conformation that is easier for Aurora A to approach. The way Bora binds Plk1 fits the classical model as Bora needs to be primed itself by CDK1 phosphorylation.
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