An example of signal transduction cascade involving cyclic AMP
The binding of adrenaline to an adrenergic receptor initiates a cascade of reactions inside the cell. The signal transduction cascade begins when adenylyl cyclase, a membrane- bound enzyme, becomes activated by G-protein molecules associated with the adrenergic receptor. Adenylyl cyclase creates multiple cyclic AMP molecules, which fan out and activate protein kinases (PKA, in this example). Protein kinases can enter the nucleus and affect transcription.
This image is linked to the following Scitable pages:
Chemical signals are continually bombarding cell. Learn how the binding of a signal to cell receptors initiates a process called signal trandsduction inside the cell that causes a chain of reactions.
Comments
CloseComments
Please Post Your Comment