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Owning the Stuff of Life

Patents on DNA have not caused the severe disruption of biomedical research and societal norms anticipated by critics. But the deluge may be yet to come


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There is a gene in your body's cells that plays a key role in early spinal cord development. It belongs to Harvard University. Another gene makes the protein that the hepatitis A virus uses to attach to cells; the U.S. Department of Health and Human Services holds the patent on that. Incyte Corporation, based in Wil¿mington, Del., has patented the gene of a receptor for histamine, the compound released by cells during the hay fever season. About half of all the genes known to be involved in cancer are patented.

Human cells carry nearly 24,000 genes that constitute the blueprint for the 100 trillion cells of our body. As of the middle of last year, the U.S. Patent and Trademark Office had issued patents to corporations, universities, government agencies and nonprofit groups for nearly 20 percent of the human genome. To be more precise, 4,382 of the 23,688 genes stored in the National Center for Biotechnology Information's database are tagged with at least one patent, according to a study published in the October 14, 2005, Science by Fiona Murray and Kyle L. Jensen of the Massachusetts Institute of Technology. Incyte alone owns nearly 10 percent of all human genes.

Gary Stix, the neuroscience and psychology editor for Scientific American, edits and reports on emerging advances that have propelled brain science to the forefront of the biological sciences. Stix has edited or written cover stories, feature articles and news on diverse topics, ranging from what happens in the brain when a person is immersed in thought to the impact of brain implant technology that alleviates mood disorders like depression. Before taking over the neuroscience beat, Stix, as Scientific American's special projects editor, oversaw the magazine's annual single-topic special issues, conceiving of and producing issues on Einstein, Darwin, climate change and nanotechnology. One special issue he edited on the topic of time in all of its manifestations won a National Magazine Award. Stix is the author with his wife Miriam Lacob of a technology primer called Who Gives a Gigabyte: A Survival Guide to the Technologically Perplexed.

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Scientific American Magazine Vol 294 Issue 2This article was originally published with the title “Owning the Stuff of Life” in Scientific American Magazine Vol. 294 No. 2 (), p. 0