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Scientific American

August 1, 2002

1 min read

The Serious Search for an Anti-Aging Pill

In government laboratories and elsewhere, scientists are seeking a drug able to prolong life and youthful vigor. Studies of caloric restriction are showing the way

By Mark A. Lane, Donald K. Ingram and George S. Roth

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2-Deoxy-D-Glucose Feeding in Rats Mimics Physiological Effects of Caloric Restriction. Mark A. Lane, George S. Roth and Donald K. Ingram in Journal of Anti-Aging Medicine, Vol. 1, No. 4, pages 327¿337; Winter 1998.

Caloric Restriction and Aging. Richard Weindruch in Scientific American, Vol. 274, No. 1, pages 46¿52; January 1996.

Caloric Restriction in Primates and Relevance to Humans. George S. Roth, Donald K. Ingram and Mark A. Lane in Annals of the New York Academy of Sciences, Vol. 928, pages 305¿315; 2001.

MARK A. LANE, DONALD K. INGRAM and GEORGE S. ROTH researched caloric restriction together for many years at the National Institute on Aging of the National Institutes of Health. Lane, who in March became a project manager at Merck and Co., in Rahway, N.J., continues to collaborate with Ingram and Roth as a guest investigator at the NIA. Ingram is chief of the Behavioral Neuroscience Section at the institute's Laboratory of Neurosciences. Roth, who spent nearly 30 years as a full-time researcher at the NIA, is now a senior guest scientist there. He is also chief executive officer of GeroTech, a new biotechnology venture devoted to anti-aging strategies.

More by Mark A. Lane, Donald K. Ingram and George S. Roth
Scientific American Magazine Vol 287 Issue 2This article was originally published with the title “The Serious Search for an Anti-Aging Pill” in Scientific American Magazine Vol. 287 No. 2 ()
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