Unblocking axonal regeneration FREE

by Tim Fulmer, Senior Writer

doi:10.1038/scibx.2009.1588

Harvard and Case Western scientists have identified a neuronal receptor responsible for impeding axonal regeneration following CNS injury. Next, the researchers plan to create antagonists of the receptor to block its antiregenerative effects.

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Norrin vs. VEGF

by Lev Osherovich, Senior Writer

doi:10.1038/scibx.2009.1589

Teams at Johns Hopkins and Genentech have identified in the retinal neovascularization pathway a trio of potential targets for diseases such as diabetic retinopathy and wet age-related macular degeneration. But further research will first have to determine whether this developmental pathway is also involved in disease and therefore druggable in the adult eye.

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Tuning the radio with CD47

by Lauren Martz, Staff Writer

doi:10.1038/scibx.2009.1590

NCI researchers think they have found a strategy that not only protects healthy tissue during radiation treatment but also enhances antitumor response, most likely by protecting tumor-infiltrating immune cells.

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AD's tangled tail

by Lev Osherovich, Senior Writer

doi:10.1038/scibx.2009.1591

A new mouse model of Alzheimer's disease suggests that an intracellular domain of amyloid precursor protein—and not β-amyloid—causes the disease. The findings could provide additional mechanistic validation for companies developing molecules that block the production of the intracellular APP domain, including BACE1 and γ-secretase inhibitors.

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Treating systemic lupus erythematosus with anti-CD126 antibodies; developing MALT1 protease inhibitors to treat lymphoma; using CD98HC inhibitors to treat vaso-occlusive diseases; treating allergic asthma with ITK antagonists; and more...

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Microdroplet-based PCR amplification; a mouse model of achromatopsia; a PCPP adjuvant for microneedle delivery of intradermal vaccines; and more...

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