Distillery: Techniques
June 25 2009, Volume 2 / Number 25
Top of pageChemistry
Targeted resequencing using filter-based hybridization
doi:10.1038/scibx.2009.1023
Filter-based hybridization of genomic targets could help detect SNPs and determine copy number variation associated with disease.
Summary - Targeted resequencing using filter-based hybridization | PDF (173 KB) - Targeted resequencing using filter-based hybridization
Total synthesis of haouamine A for cancer treatment
doi:10.1038/scibx.2009.1024
A scalable method for synthesizing haouamine A and its isomers could provide sufficient amounts of the compound to treat cancer.
Summary - Total synthesis of haouamine A for cancer treatment | PDF (174 KB) - Total synthesis of haouamine A for cancer treatment
Disease models
Mouse model of spontaneous relapsing-remitting multiple sclerosis (MS)
doi:10.1038/scibx.2009.1025
Transgenic mice expressing a T cell receptor specific for a myelin oligodendrocyte glycoprotein (MOG)-derived peptide could serve as a model for relapsing-remitting MS.
Summary - Mouse model of spontaneous relapsing-remitting multiple sclerosis (MS) | PDF (175 KB) - Mouse model of spontaneous relapsing-remitting multiple sclerosis (MS)
Drug delivery
Magnetic nanoparticle (MNP)-assisted adenoviral gene transfer
doi:10.1038/scibx.2009.1026
Adenovirus-loaded MNPs may be useful for delivering gene therapy.
Summary - Magnetic nanoparticle (MNP)-assisted adenoviral gene transfer | PDF (174 KB) - Magnetic nanoparticle (MNP)-assisted adenoviral gene transfer
Radioimmunotherapy to enhance delivery of radiation to cancer cells
doi:10.1038/scibx.2009.1027
Studies in primates suggest that anti-CD45–based radioimmunotherapy could enhance efficacy of radiotherapy in leukemias and lymphomas.
Summary - Radioimmunotherapy to enhance delivery of radiation to cancer cells | PDF (172 KB) - Radioimmunotherapy to enhance delivery of radiation to cancer cells
