Distillery: Techniques

Mouse model of spontaneous relapsing-remitting multiple sclerosis (MS)

Published online June 25 2009; doi:10.1038/scibx.2009.1025

Transgenic mice expressing a T cell receptor specific for a myelin oligodendrocyte glycoprotein (MOG)-derived peptide could serve as a model for relapsing-remitting MS.

Summary - Mouse model of spontaneous relapsing-remitting multiple sclerosis (MS) | PDF (175 KB) - Mouse model of spontaneous relapsing-remitting multiple sclerosis (MS)

Tools

A first for monkey models

by Tracey Baas, Associate Editor

Published online June 18 2009; doi:10.1038/scibx.2009.964

Japanese researchers have developed the first transgenic nonhuman primates that pass transgenes to their progeny. The approach could provide a boon to the study of specific inherited diseases and conditions determined by disease susceptibility genes.

Full text - A first for monkey models | PDF (167 KB) - A first for monkey models

Distillery: Techniques

Mouse model of Parkinson's disease (PD)

Published online June 18 2009; doi:10.1038/scibx.2009.991

Transgenic mice expressing a mutant form of the leucine-rich repeat kinase 2 (LRRK2) could help guide the development of neuroprotective PD therapies.

Summary - Mouse model of Parkinson's disease (PD) | PDF (110 KB) - Mouse model of Parkinson's disease (PD)

Distillery: Techniques

Chimeric mouse model of airway epithelial stem cell function

Published online June 11 2009; doi:10.1038/scibx.2009.956

A chimeric mouse model of airway epithelial stem cell function could help identify new treatments for pulmonary disease.

Summary - Chimeric mouse model of airway epithelial stem cell function | PDF (111 KB) - Chimeric mouse model of airway epithelial stem cell function

Distillery: Techniques

Transgenic marmoset-based disease models with germline transmission

Published online June 11 2009; doi:10.1038/scibx.2009.957

Transgenic marmosets with germline transmission of human genes could provide a useful primate model to study human diseases.

Summary - Transgenic marmoset-based disease models with germline transmission | PDF (112 KB) - Transgenic marmoset-based disease models with germline transmission

Distillery: Techniques

Model of progenitor cell fates following spinal cord injury (SCI)

Published online June 4 2009; doi:10.1038/scibx.2009.924

A model of progenitor cell fate following injury could aid in the design of new SCI therapies.

Summary - Model of progenitor cell fates following spinal cord injury (SCI) | PDF (174 KB) - Model of progenitor cell fates following spinal cord injury (SCI)