Distillery: Therapeutics

Cardiac hypertrophy

Hypoxia-inducible factor 1 (HIF1A; HIF1); peroxisome proliferation–activated receptor- (PPARG; PPAR)

Published online June 25 2009; doi:10.1038/scibx.2009.1005

Studies in mice and in cell culture suggest that inhibiting HIF1 could be useful for preventing cardiac hypertrophy.

Summary - Hypoxia-inducible factor 1 (HIF1A; HIF1); peroxisome proliferation–activated receptor- (PPARG; PPAR) | PDF (113 KB) - Hypoxia-inducible factor 1 (HIF1A; HIF1); peroxisome proliferation–activated receptor- (PPARG; PPAR)

Distillery: Therapeutics

Fibrillation

Calcium calmodulin-dependent protein kinase II (CAMK2); ryanodine receptor 2 (RyR2)

Published online June 25 2009; doi:10.1038/scibx.2009.1006

In vivo and tissue studies suggest that antagonizing CAMK2 could help treat atrial fibrillation.

Summary - Calcium calmodulin-dependent protein kinase II (CAMK2); ryanodine receptor 2 (RyR2) | PDF (112 KB) - Calcium calmodulin-dependent protein kinase II (CAMK2); ryanodine receptor 2 (RyR2)

Distillery: Therapeutics

Heart failure

Unknown

Published online June 25 2009; doi:10.1038/scibx.2009.1007

Studies in canines and in tissue culture suggest that a modified B-type natriuretic peptide (ASBNP.1) could help treat heart failure with fewer renal side effects than first-generation peptides.

Summary - Unknown | PDF (114 KB) - Unknown

Distillery: Therapeutics

Hypercholesterolemia

Liver X receptor- (NR1H3; LXR-); NR1H2 (LXR-); myosin regulatory light chain interacting protein (MYLIP; IDOL)

Published online June 25 2009; doi:10.1038/scibx.2009.1008

A study in human and mouse cell culture suggests that antagonizing IDOL could help lower cholesterol.

Summary - Liver X receptor- (NR1H3; LXR-); NR1H2 (LXR-); myosin regulatory light chain interacting protein (MYLIP; IDOL) | PDF (114 KB) - Liver X receptor- (NR1H3; LXR-); NR1H2 (LXR-); myosin regulatory light chain interacting protein (MYLIP; IDOL)

Distillery: Therapeutics

Endothelial cell nitric oxide synthase 3 (NOS3; eNOS); protein kinase cGMP-dependent type 1 (PRKG1; PKG1)

Published online June 11 2009; doi:10.1038/scibx.2009.940

A study in patients and in mice suggests that blocking PKG1 nitration or inhibiting eNOS could help treat pulmonary hypertension.

Summary - Endothelial cell nitric oxide synthase 3 (NOS3; eNOS); protein kinase cGMP-dependent type 1 (PRKG1; PKG1) | PDF (114 KB) - Endothelial cell nitric oxide synthase 3 (NOS3; eNOS); protein kinase cGMP-dependent type 1 (PRKG1; PKG1)

Cover Story

The secreted secret of PCSK9 FREE

by Kai-Jye Lou, Staff Writer

Published online June 4 2009; doi:10.1038/scibx.2009.895

Amgen researchers have demonstrated that blocking secreted PCSK9 in mice and nonhuman primates lowers LDL cholesterol. The findings bolster the case for an antibody-based approach to blocking the protein, which is a genetically validated target for hypercholesterolemia.

Full text - The secreted secret of PCSK9 | PDF (332 KB) - The secreted secret of PCSK9

Distillery: Therapeutics

Serotonin (5-HT₃) receptor (HTR_3A)

Published online June 4 2009; doi:10.1038/scibx.2009.907

In vitro and rodent studies suggest that a series of pyrroloquinoxaline analogs could help treat cardiovascular conditions.

Summary - Serotonin (5-HT3) receptor (HTR3A) | PDF (111 KB) - Serotonin (5-HT3) receptor (HTR3A)

Distillery: Therapeutics

MicroRNA-92a (miRNA-92a)

Published online June 4 2009; doi:10.1038/scibx.2009.908

A study in mice and in cell culture suggests that inhibiting miRNA-92a could help treat ischemia and MI.

Summary - MicroRNA-92a (miRNA-92a) | PDF (112 KB) - MicroRNA-92a (miRNA-92a)

Distillery: Therapeutics

Superoxide dismutase 2, mitochondrial (SOD2); signal transducer and activator of transcription 3 (STAT3)

Published online June 4 2009; doi:10.1038/scibx.2009.909

Studies in primary cell culture and in mice suggest that STAT3 agonists could prevent brain damage after cerebral ischemia.

Summary - Superoxide dismutase 2, mitochondrial (SOD2); signal transducer and activator of transcription 3 (STAT3) | PDF (111 KB) - Superoxide dismutase 2, mitochondrial (SOD2); signal transducer and activator of transcription 3 (STAT3)