Original Article
Spinal Cord (2008) 46, 189–191; doi:10.1038/sj.sc.3102095; published online 3 July 2007
Amenorrhoea in newly spinal cord injured women: an effect of hyperprolactinaemia?
L Rutberg1, B Fridén2 and A-K Karlsson1
- 1Spinal Injury Unit, Institution of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg, Sweden
- 2Spinal Injury Unit, Department of Obstetrics and Gynaecology, Institution of Clinical Sciences, Sahlgrenska Academy, Göteborg, Sweden
Correspondence: Dr L Rutberg, Spinal Injury Unit, Institution of Neuroscience and Physiology, Sahlgrenska Academy, S 413 45 Göteborg, Sweden. E-mail: lena.rutberg@vgregion.se
Received 19 October 2006; Revised 20 April 2007; Accepted 12 May 2007; Published online 3 July 2007.
Abstract
Study design:
Prospective, single centre study.
Objectives:
Previous studies have suggested a relationship between stress reaction and elevated levels of prolactine. The aim of the present study was to investigate if there was a relationship between s-prolactine and menstrual cycle status following spinal cord injury (SCI).
Setting:
Spinal Cord Injury Unit, Göteborg, Sweden.
Methods:
S-prolactine and menstrual cycle status were investigated in 16 consecutive women with SCI, treated at the SCI Unit, Sahlgrens University Hospital, Göteborg, Sweden. Level of injury ranged from C1 to L5, ASIA A–D. Mean age at injury was 45 years (range 20–79).
Results:
S-Prolactine showed a mean value of 741 mIU/l (standard deviation (s.d.): 625; 95% confidence interval (CI): 435–1788 mIU/l, reference value <400 mIU/l). When dividing the group according to fertility status we found hyperprolactinaemia in the women who were in childbearing age (n=9): mean value 1050 mIU/l (s.d.: 678; 95% CI: 607–1493 mIU/ml), whereas it was normal in the group in menopause (n=7): mean value 343 mIU/l (s.d.: 185, 95% CI: 206–480 mIU/l) (P<0.01 when comparing groups). The group that developed amenorrhoea showed the highest values of s-prolactine. All values but one was normalised 3–6 months later.
Conclusion:
Amenorrhoea following SCI is correlated to level of s-prolactine. We found no correlation between level of s-prolactine and level or degree of injury.
Keywords:
spinal cord injury, woman, prolactine, amenorrhoea, menopause
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