Proteus bacteriuria is associated with significant morbidity in spinal cord injury

doi:doi:10.1038/sj.sc.3102004

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Abstract

Study Design:

Retrospective chart review.

Objectives:

We investigated the morbidity associated with Proteus bacteriuria in a spinal cord injured (SCI) population.

Setting:

Michael E DeBakey Veterans Affairs Medical Center in Houston, Texas, USA.

Methods:

We reviewed the medical records of all veterans with SCI who received care in our medical center during the past 3 years. Proteus bacteriuria was defined as the growth of Proteus species in any urine culture during the study period. Urinary stones were defined as either renal or bladder calculi.

Results:

During the study period, 71 of the 501 subjects (14%) had Proteus and 90 (18%) had urinary stones. Twenty-seven percent of the subjects with Proteus had stones, and the association of Proteus with stones was significant (P<0.05). Proteus bacteriuria was likewise associated with complete injury, hospitalization, decubitus ulcers, and history of stones (P<0.001). Subjects using indwelling catheters, either transurethral or suprapubic, were significantly more likely to have Proteus, whereas subjects practising spontaneous voiding and clean intermittent catheterization were significantly less likely to have Proteus. In the 90 patients with stones, Proteus was associated with requiring treatment for stones and having multiple stones (P<0.01). Twenty-five of the 90 patients with stones (28%) required treatment, most often with lithotripsy, and 6 (7%) developed urosepsis.

Conclusions:

In persons with SCI, Proteus was found in subjects with a greater degree of impairment who were more likely to be hospitalized, to have decubiti, and to use indwelling catheters. Bacteriuria with Proteus predicted urologic complications in persons with SCI.

Statement of Ethics:

All applicable institutional and governmental regulations concerning the ethical use of human volunteers were followed during the course of this research.

Sponsorship:

This work was supported by USPHS grant HD42014.

Keywords:

spinal cord injury, bacteriuria, Proteus, urinary stones

Original Article