Case Report
Spinal Cord (2006) 44, 330–333. doi:10.1038/sj.sc.3101838; published online 20 September 2005
Aseptic meningitis after intrathecal baclofen injection
D Bensmail1, A Peskine1, P Denys1, L Bernard2 and B Bussel1
- 1Service de Médecine Physique et Réadaptation, Hôpital R Poincaré, Garches, France
- 2Service de maladies infectieuses et médecine interne, Hôpital R Poincaré, Garches, France
Correspondence: D Bensmail, Service de Médecine Physique et Réadaptation, Hôpital R. Poincaré, 104 Bd R. Poincaré, 92380 Garches, France
Abstract
Study design:
Two case reports of aseptic meningitis after intrathecal baclofen injection.
Objectives:
To report an unusual complication of intrathecal baclofen injection during test injections.
Setting:
Department of Neurological Rehabilitation, R Poincaré Hôpital (Paris-Ile de France-Ouest University).
Case reports:
We present two cases of chemical meningitis after intrathecal baclofen injections by lumbar puncture. These cases presented with febrile meningeal syndromes during the 24 h following intrathecal baclofen injection. Direct cerebrospinal fluid (CSF) examination and CSF cultures were negative. An intense cellular reaction was observed with a marked predominance of neutrophils. Meningitis resolved spontaneously over 3–4 days.
Conclusions:
Chemical meningitis is a rare complication of intrathecal baclofen injections that must be recognized. It is a diagnosis of exclusion and its pathophysiological mechanism remains unclear.
Keywords:
intrathecal baclofen, chemical meningitis, complications
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