TABLE 1
FROM:
Effect of postinjury intravenous or intrathecal methylprednisolone on spinal cord excitatory amino-acid release, nitric oxide generation, PGE2 synthesis, and myeloperoxidase content in a pig model of acute spinal cord injury
C M Bernards and T Akers
BACK TO ARTICLETable 1. Pharmacokinetic parameters
| Sampling site | Group | ||
|---|---|---|---|
| Saline | Intravenous methylprednisolone | Intrathecal methylprednisolone | |
| CSF at injury site | |||
| Peak concentration (fractions of baseline) | |||
| Aspartate | 3.3 1.7 | 4.82.6 | 4.63.8 |
| Glutamate | 2.61.2 | 3.31.5 | 3.11.6 |
| Citrulline | 1.90.4 | 2.20.7 | 1.90.7 |
| PGE2 | 9.58.7 | 10.88.6 | 10.510.6 |
| Time to peak concentration (min) | |||
| Aspartate | 14628 | 1389.5 | 15856 |
| Glutamate | 14521 | 14010 | 15345 |
| Citrulline | 23072 | 27286 | 23785 |
| PGE2 | 15743 | 18884 | 1407.5 |
AUC (fraction of baseline  time)
| |||
| Aspartate | 389194 | 385118 | 408192 |
| Glutamate | 324167 | 30882 | 332176 |
| Citrulline | 353109 | 378152 | 344131 |
| PGE2 | 448239 | 530263 | 559255 |
| CSF at proximal control site | |||
| Peak concentration (fraction of baseline) | |||
| Aspartate | 2.00.8 | 2.52.1 | 2.41.6 |
| Glutamate | 1.91.0 | 2.72.0 | 2.01.4 |
| Citrulline | 1.70.5 | 1.80.8 | 1.70.6 |
| PGE2 | 1.71.3 | 4.75.8 | 3.52.5 |
| Time to peak concentration (min) | |||
| Aspartate | 24882 | 24582 | 23484 |
| Glutamate | 25188 | 25999 | 19367 |
| Citrulline | 23666 | 31174 | 25483 |
| PGE2 | 18366 | 17870 | 19580 |
| AUC (fraction of baseline time)
| |||
| Aspartate | 27781 | 264124 | 291132 |
| Glutamate | 296127 | 317164 | 293154 |
| Citrulline | 30064 | 30595 | 30982 |
| PGE2 | 195101 | 266154 | 394433 |
