The Queen Elizabeth National Spinal Injuries Unit and Department of Neuroradiology, Southern General Hospital, Glasgow, UK

Correspondence to: R C Prempeh, The Queen Elizabeth National Spinal Injuries Unit, and Department of Neuroradiology, Southern General Hospital, NHS Trust, 1345 Govan Road, Glasgow, G51 4FT.

Congenital clefts and other developmental anomalies of the atlas vertebra are rarely encountered. They are incidental findings discovered while investigating the cervical spine following trauma. Differentiation of developmental variants of the atlas from the burst fracture of Jefferson is essential to prevent unnecessary medical intervention.

Spinal Cord (2002) 40, 92-93 DOI: 10.1038/sj/sc/3101230

mid-line cleft; atlas; Jefferson fracture

Case history

A 29-year-old snow boarder swerved to avoid a skier. He somersaulted and landed on his back. There was no history of head injury or loss of consciousness. He walked into the examination room complaining of neck pain but with no radiation of the pain to his arms or sub-occipitally. Lhermitte's sign was not reported, and neurological examination was normal. Antero-posterior and lateral cervical spine radiography down to C7/T1, including flexion/extension views, were normal. Open-mouth radiography revealed a mid-line defect in the anterior arch of the atlas (Figure 1), which raised the suspicion of a fracture. Computed tomography (CT) confirmed the presence of a congenital anterior mid-line cleft and also showed a similar mid-line cleft in the posterior arch (Figure 2). The patient was reassured and treated symptomatically with simple analgesics. On review 1 week later he was completely free of neck pain.

Discussion

Ossification of the posterior arch of the atlas begins around the seventh week of intra-uterine life in two centres of ossification, one in each half of the posterior arch. The endochondrial ossification proceeds dorsally, and fusion usually occurs around the third year of life. In about 2% of infants another ossification centre in the region of the posterior tubercle is found, uniting secondarily with the lateral processes of the arch.^1,2 The anterior arch develops from one or more ossification centres, which usually appear during the first year of life. Fusion of the anterior arch to the lateral masses, to form the neurocentral synchrondrosis, normally occurs by the seventh year of life (Figure 3).^3,4

Posterior mid-line clefts of the atlas, rachischisis or spina bifida occulta, are well recognised and are attributed to the defective or absent development of the cartilaginous preformation of the arch and not to a disturbance of the ossification.⁵ Geipel noted in 1613 dissections of the atlas that 4% had a cleft of the posterior arch; 97% of these were median clefts, while the rest were located laterally through the sulcus of the vertebral artery.⁶

Anterior mid-line clefts, however, are much rarer, accounting for only 0.1% in the Geipel series.⁶ In this case the ossification centre in the anterior arch of the atlas fails to develop. The arch is thus formed from ventral extensions of the lateral masses that fail to fuse anteriorly. These mid-line clefts are usually associated with posterior mid-line clefts, as in our patient, and are seldom found in isolation.⁷

Differentiation of developmental anomalies, particularly clefts of the atlas from the more common Jefferson burst fracture needs to be made as soon as possible after the suspicion is raised. This is necessary not only to allay the anxieties of the patient and medical staff, but also to commence definite management, which differs drastically between the two conditions. In the case of the mid-line clefts of the atlas, provided that ligamentous and bony injury has been excluded by appropriate imaging, definitive management is usually symptomatic with simple analgesics if necessary. With the Jefferson fracture however, treatment consists of external immobilisation of the cervical spine with a Sternal Occipital Mandibular Immobilisation (SOMI) brace or Halo fixation vest for up to 16 weeks.⁸

Differentiation of the developmental anomalies from burst fractures of the atlas can be made from close inspection of the lateral cervical and open-mouth radiographs and confirmed by CT. On the lateral radiograph the cortical bone of the anterior arch may be absent or indistinct when a cleft is present.⁷ Linear tomography may further reveal smooth corticated margins, which contrast with the sharp non-corticated appearance of a fracture. In addition, developmental anomalies may be associated with an atlanto-axial lateral offset of 1-2 mm if there are both anterior and posterior defects. This, however, does not indicate abnormal spread of the atlas and is not clinically significant. A Jefferson fracture should be suspected with an offset greater than 3 mm in an adult (Figure 4).⁹

Conclusion

It is important to differentiate congenital mid-line clefts of the atlas from a Jefferson fracture. This can be done by close inspection of the plain radiographs, and confirmed by CT.

1 Von Torklus D, Gehle W. The upper cervical spine Grune & Stratton: New York, 1972, 25.

2 Gehweiler J, Osbourne R, Becker R. The Radiology of Vertebral Trauma Saunders: Philadelphia, 1980, p 55.

3 Warwick R, Williams PL (eds). Gray's Anatomy 36th Ed Churchill Livingstone (Edinburgh), 1980, 3, 283-.

4 Wackenheim A. Roentgen Diagnosis of the Craniovertebral Region Springer-Verlag: Berlin, Heidelberg, New York, 1974, p 199.

5 Geipel P. Zur Kenntnis der spanltbildungen des Atlas und Epistopheus. Teil IV. Zentralbl Allg Pathol 1955; 94: 19-84.

6 Schulze P, Buurman R. Absence of the posterior arch of the atlas. Am J Roent 1980; 134: 178-180.

7 Gehweiler J, Daffner R, Roberts L. Malformation of the atlas vertebra simulating the Jefferson fracture. Am J Roent 1983; 140: 1083-1086.

8 Hadley M et al. Acute Traumatic Atlas Fractures: Management and Long-Term Outcome. Neurosurgery 1988; 23: 31-35. MEDLINE

9 Chambers A, Gaskill M. Mid-line anterior atlas clefts: CT findings. Journal of Computer Assisted Tomography 1992; 16: 868-870. MEDLINE

Figure 1 AP open-mouth radiograph. Note the lucent vertical cleft of the odontoid process (arrows)

Figure 2 Axial CT through the Atlas vertebra on bone windows. Note the well corticated and well defined anterior and posterior fusion defects (arrow) with no associated subluxation or soft tissue swelling

Figure 3 Line diagram of the ossification centres of the atlas

Figure 4 AP open-mouth radiograph. Note the bilateral displacement of the lateral masses (arrows)