¹Department of Internal Medicine, St Elizabeth Health Center, Youngstown, Ohio, OH 44501, USA

²Hillside Rehabilitation Hospital, Warren, Ohio, OH 44501, USA

³Northeastern Ohio Universities College of Medicine, Department of Medicine, Rootstown, Ohio, OH 44272-0095, USA

Correspondence to: B Dass, Department of Research, St. Elizabeth Health Center, 1044 Belmont Avenue, Youngstown, OH 44501, USA

Study design: Case reports and survey of literature.

Objective: Case reports of two women with tuberculosis (TB) of the spine (Pott's disease) presenting with severe back pain and diagnosed as compression fracture are described. Physicians should include Pott's disease in the differential diagnosis when patients present with severe back pain and evidence of vertebral collapse.

Setting: Ohio, USA

Methods: A review of the literature on the pathogenesis, pathophysiology, clinical presentation, diagnostic methods, treatment and prognosis of spinal TB was conducted.

Results: After initial delay, proper diagnosis of spinal TB was made in our patients. Microbiologic diagnosis confirmed M. tuberculosis, and appropriate medical treatment was initiated.

Conclusions: Although uncommon, spinal TB still occurs in patients from developed countries, such as the US and Europe. Back pain is an important symptom. Vertebral collapse from TB may be misinterpreted as 'compression fractures' especially in elderly women. Magnetic resonance imaging scan (MRI) is an excellent procedure for the diagnosis of TB spine. However, microbiologic diagnosis is essential. Mycobacterium tuberculosis may be cultured from other sites. Otherwise, biopsy of the spine lesion should be done for pathologic diagnosis, culture and stain for M. tuberculosis. Clinicians should consider Pott's disease in the differential diagnosis of patients with back pain and destructive vertebral lesions. Proper diagnosis and anti-tuberculosis treatment with or without surgery will result in cure.

Spinal Cord (2002) 40, 604-608. doi:10.1038/sj.sc.3101365

tuberculosis; Pott's disease; tuberculosis of spine; compression fracture