Nature Reviews Neuroscience

Volume 9, No 5 May 2008

Featured Article

GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition

Tija C. Jacob, Stephen J. Moss & Rachel Jurd

Advance online publication

Review

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia


Lin Mei & Wen–Cheng Xiong

Polymorphisms in the genes that encode neuregulin 1 (NRG1) and its receptor ErbB4 have been associated with schizophrenia. Mei and Xiong review the role of NRG1 signalling in neural development and synaptic plasticity and discuss how alterations in NRG1 signalling might contribute to schizophrenia.

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Review

The neural systems that mediate human perceptual decision making


Hauke R. Heekeren, Sean Marrett & Leslie G. Ungerleider

Heekeren and colleagues review neurophysiological and neuroimaging studies of monkeys and humans making perceptual decisions, highlighting both the similarities and the differences in their decision-making processes and providing a new model for the neural architecture that underlies perceptual decision making in humans.

Advance online publication

Review

Presynaptic glutamate receptors: physiological functions and mechanisms of action

Paulo S. Pinheiro & Christophe Mulle

Our understanding of the functional roles of presynaptic glutamate receptors continues to grow. Pinheiro and Mulle capture the current state of this knowledge, describing the modes and mechanisms of action of these receptors and the evidence for their contributions to synaptic transmission.

Advance online publication

Progress

A technicolour approach to the connectome



Jeff W. Lichtman, Jean Livet & Joshua R. Sanes

New technologies promise to decipher whole-brain connectivity at a much greater resolution than ever before. Here, Lichtman, Livet and Sanes, the creators of Brainbow, critically assess the applications and challenges of this technology and those of other existing and emerging technologies.

Advance online publication

Research Highlights

Current issue

Poster

Amyloid–β and tau in Alzheimer's disease


Frank M. LaFerla

Frank LaFerla provides up–to–date information on the interlinked signalling pathways associated with amyloid–β and tau, the contribution of these two proteins to Alzheimer’s disease (AD) pathology, and current and potential drug targets for the treatment of AD.

The Poster is freely available thanks to support from Elan and Wyeth.

More Neuroscience

Noticeboard

Memory systems series

A special series of articles highlighting different types of memory and how they are represented in the brain.

Signalling in development series

A special series of articles highlighting recent progress in our understanding of the molecular mechanisms that are involved in all aspects of neural development.

Neuroimaging series

A special series of articles highlighting applications of neuroimaging techniques in all areas of neuroscience, including basic neurobiology, cognitive and behavioural neuroscience, translational neurology and clinical practice.

Journal Citation Reports, Thomson, 2007

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