Sigma-Aldrich offers a range of new and exciting technologies for Systems Biology Research:

The TargeTron™ Gene Knockout System is a revolutionary method for rapid and specific disruption of genes in prokaryotic organisms, ideal for genetic engineering, systems biology and functional genomics approaches.

The method exploits the retrohoming ability of group II introns and utilises a simple PCR step to "re-target" the TargeTron group II intron for specific insertion into the host genome. The technology has been validated in a broad range of bacterial strains such as Escherichia coli , Staphylococcus aureus, Lactococcus lactis, Clostridium perfringens, Shigella flexneri and Salmonella typhimurium.

www.sigma-aldrich.com/targetron

GenomePlex® Whole Genome Amplification (WGA) kit for robust and accurate amplification of limited source DNA. GenomePlex WGA works by randomly digesting the DNA template into a fragmented library. This is then converted to PCR-amplifiable molecules flanked by universal priming sites. Subsequent amplification by standard PCR results in whole genome amplification. Amplified DNA is suitable for a range of genetic analyses.

www.sigma-aldrich.com/wga

Finally, protein microarrays of biologically-related human cancer proteins that retain their native function. The Panorama™ Human Protein Function Microarrays for Cancer and p53, contain proteins that are implicated in oncogenesis and are important germline SNP variants of p53 respectively.

www.sigma-aldrich.com/proteinarray