NPG Library
Below is a selection of recent content from a range of Nature Publishing Group journals on the topic of Stem cells.
Research Highlights
Stem cells: Ringing the changes
Francesca Cesari
doi:10.1038/nrm2314
Nature Reviews Molecular Cell Biology 9, 6-7 (2008)
Microenvironment: A disturbed background
Nicola McCarthy
doi:10.1038/nrc2194
Nature Reviews Cancer 7, 566 (2007)
Fishing for clues
Francesca Pentimalli
doi:10.1038/nrc2181
Nature Reviews Cancer 7, 490-491 (2007)
The environment matters
Rebecca Robey
doi:10.1038/nrc2092
Nature Reviews Cancer 7, 160 (2007)
Early signs of trouble ahead
Louisa Flintoft
doi:10.1038/nrc2081
Nature Reviews Cancer 7, 72 (2007)
BMPs on the brain
Francesca Pentimalli
doi:10.1038/nrc2065
Nature Reviews Cancer 7, 4 (2007)
Stem cells: Exception to the rule?
Arianne Heinrichs
doi:10.1038/nrm2279
Nature Reviews Molecular Cell Biology 8, 851 (2007)
Introducing the next generation
Ekat Kritikou
doi:10.1038/nrm2211
Nature Reviews Molecular Cell Biology 8, 512 (2007)
Sharing common factors for self-renewal
Ekat Kritikou
doi:10.1038/nrm2181
Nature Reviews Molecular Cell Biology 8, 425 (2007)
Epidermis — a population in question
Ekat Kritikou
doi:10.1038/nrm2151
Nature Reviews Molecular Cell Biology 8, 273 (2007)
Fledglings escape from the niche
James Pickett
doi:10.1038/nrm2132
Nature Reviews Molecular Cell Biology 8, 177 (2007)
Avoiding commitment
James Pickett
doi:10.1038/nrm2115
Nature Reviews Molecular Cell Biology 8, 99 (2007)
The potential of networking
Shannon Amoils
doi:10.1038/nrm2071
Nature Reviews Molecular Cell Biology 7, 881 (2006)
Nanog: the gift of choice
Shannon Amoils
doi:10.1038/nrm1994
Nature Reviews Molecular Cell Biology 7, 555 (2006)
Poised for action
Louisa Flintoft
doi:10.1038/nrm1948
Nature Reviews Molecular Cell Biology 7, 383 (2006)
Cell migration: Immunosurveillance by recirculating HSPCs
Marta Tufet
doi:10.1038/nri2242
Nature Reviews Immunology 8, 2 (2008)
Stem cells: Safeguarding pluripotency
Louisa Flintoft
doi:10.1038/nrg2306
Nature Reviews Genetics 9, 86-87 (2008)
Reviews
MLL translocations, histone modifications and leukaemia stem-cell development
Andrei V. Krivtsov & Scott A. Armstrong
doi:10.1038/nrc2253
Nature Reviews Cancer 7, 823-833 (2007)
Mixed lineage leukaemia (MLL) has histone methyltransferase activity and regulates the expression of genes such as Hox genes. This activity is lost in MLL fusion proteins resulting from inter-chromosomal translocations, which are leukemogenic. How do MLL fusions function and what is their role in leukaemia stem cells?
Myelodysplastic syndromes: the complexity of stem-cell diseases
Seth J. Corey, Mark D. Minden, Dwayne L. Barber, Hagop Kantarjian, Jean C. Y. Wang & Aaron D. Schimmer
doi:10.1038/nrc2047
Nature Reviews Cancer 7, 118-129 (2007)
The term myelodysplastic syndromes covers various diseases that are caused by ineffective haematopoiesis in one or more lineages of the bone marrow. How do these diseases arise, and what are the best methods for treating these patients?
Epigenetic signatures of stem-cell identity
Mikhail Spivakov & Amanda G. Fisher
doi:10.1038/nrg2046
Nature Reviews Genetics 8, 263-271 (2007)
How do stem cells keep the genes that drive differentiation in a repressed state, while maintaining the ability to express them in the future? Increasing evidence indicates that distinctive epigenetic traits underlie this unique aspect of stem-cell biology.
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
Keith W. Orford & David T. Scadden
doi:10.1038/nrg2269
Nature Reviews Genetics 9, 115-128 (2008)
Cell-cycle regulation is emerging as a crucial aspect of the ability of stem cells to self-renew. Genetic studies in mice have provided insights into the nature of this regulation, highlighting shared principles in embryonic and adult stem cells.
No place like home: anatomy and function of the stem cell niche
D. Leanne Jones & Amy J. Wagers
doi:10.1038/nrm2319
Nature Reviews Molecular Cell Biology 9, 11-21 (2008)
The balance between stem cell self-renewal and differentiation is ultimately controlled by the integration of intrinsic factors with extrinsic cues supplied by the surrounding microenvironment, known as the stem cell niche. How much do we know about this intriguing microenvironment?
Derive and conquer: sourcing and differentiating stem cells for therapeutic applications
Irina Klimanskaya, Nadia Rosenthal & Robert Lanza
doi:10.1038/nrd2403
Nature Reviews Drug Discovery 7, 131-142 (2007)
The success of stem-cell-based therapies depends on finding reliable sources of multipotent and pluripotent cells, and the ability to generate desired derivatives. Here, the authors discuss problems associated with the sourcing of human embyonic stem cells and discuss the current status of stem-cell differentiation technology.
Uncertainty in the niches that maintain haematopoietic stem cells
Mark J. Kiel & Sean J. Morrison
doi:10.1038/nri2279
Nature Reviews Immunology advance online publication, 07 Mar 2008
Maintenance of haematopoietic stem cells occurs in niches, but much discussion still surrounds the precise site and nature of these niches. Here, Mark Kiel and Sean Morrison review various niche models that are compatible with the recent published data.
Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning
Xiangzhong Yang, Sadie L Smith, X Cindy Tian, Harris A Lewin, Jean-Paul Renard & Teruhiko Wakayama
doi:10.1038/ng1973
Nature Genetics 39, 295-302 (2007)
Scalable human ES culture for therapeutic use: propagation, differentiation, genetic modification and regulatory issues
M Rao
doi:10.1038/sj.gt.3303061
Gene Therapy 15, 82-88 (2007)
Directing human embryonic stem cells to generate vascular progenitor cells
H Bai & Z Z Wang
doi:10.1038/sj.gt.3303005
Gene Therapy 15, 89-95 (2007)
A niche opportunity for stem cell therapeutics
G B Adams & D T Scadden
doi:10.1038/sj.gt.3303063
Gene Therapy 15, 96-99 (2007)
Unraveling the complex regulation of stem cells: implications for aging and cancer
E J Oakley & G Van Zant
doi:10.1038/sj.leu.2404530
Leukemia 21, 612-621 (2007)
A hypothesis for an embryonic origin of pluripotent Oct-4+ stem cells in adult bone marrow and other tissues
M Z Ratajczak, B Machalinski, W Wojakowski, J Ratajczak & M Kucia
doi:10.1038/sj.leu.2404630
Leukemia 21, 860-867 (2007)
Migration, fate and in vivo imaging of adult stem cells in the CNS
E Syková & P Jendelová
doi:10.1038/sj.cdd.4402140
Cell Death and Differentiation 14, 1336-1342 (2007)
Hematopoietic stem cells: generation and self-renewal
X Huang, S Cho & G J Spangrude
doi:10.1038/sj.cdd.4402225
Cell Death and Differentiation 14, 1851-1859 (2007)
Relationships between stem cell exhaustion, tumour suppression and ageing
Y Ruzankina and E J Brown
doi:10.1038/sj.bjc.6604029
British Journal of Cancer 97, 1189-1193 (2007)
Telomere and telomerase in stem cells
E Hiyama and K Hiyama
doi:10.1038/sj.bjc.6603671
British Journal of Cancer 96, 1020-1024 (2007)
Stem cells of ependymoma
H Poppleton and R J Gilbertson
doi:10.1038/sj.bjc.6603519
British Journal of Cancer 96, 6-10 (2006)
Perspectives
Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis
John Stingl & Carlos Caldas
doi:10.1038/nrc2212
Nature Reviews Cancer 7, 791-799 (2007)
Can the heterogeneity of breast cancer be interpreted through a comparison with haematological cancers?
MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
Fiona M. Watt, Michaela Frye & Salvador Aznar Benitah
doi:10.1038/nrc2328
Nature Reviews Cancer 8, 234-242 (2008)
The discovery that the oncogene MYC can stimulate differentiation rather than proliferation in human epidermal stem cells was, understandably, greeted with scepticism. However, subsequent studies have revealed important concepts that are relevant to the function of MYC in tumorigenesis.
Making a tumour's bed: glioblastoma stem cells and the vascular niche
Richard J. Gilbertson & Jeremy N. Rich
doi:10.1038/nrc2246
Nature Reviews Cancer 7, 733-736 (2007)
Glioblastoma stem cells might be dependent on cues from aberrant vascular niches that mimic the normal neural stem cell niche. What are the implications of these findings for treatment of this disease?
From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research
Davor Solter
doi:10.1038/nrg1827
Nature Reviews Genetics 7, 319-327 (2006)
The recent eruption of interest in embryonic stem cell research is fuelled by the promise and potential of this work. But current work is firmly grounded in several decades of fascinating research that are engagingly summarized here by the author.
Can we develop ethically universal embryonic stem-cell lines?
Ronald M Green
doi:10.1038/nrg2066
Nature Reviews Genetics 8, 480-485 (2007)
New approaches to the derivation of human embryonic stem cells are being developed, with the aim of getting around the ethical questions that surround standard techniques. But are any of these new methods really free from ethical objections?
Embryonic stem cells as a source of models for drug discovery
Colin W. Pouton & John M. Haynes
doi:10.1038/nrd2194
Nature Reviews Drug Discovery 6, 605-616 (2007)
Embryonic stem cells (ESCs) can be used as a source of cellular models for a wide range of adult differentiated cells, providing that reliable differentiation protocols are established. Here, Pouton and Haynes discuss challenges and opportunities regarding the use of ESC-derived models for drug discovery.
OPINION
Epidermal homeostasis: do committed progenitors work while stem cells
sleep?
Philip Jones & Benjamin D. Simons
doi:10.1038/nrm2292
Nature Reviews Molecular Cell Biology 9, 82-88 (2008)
Studies of epidermis in vivo have revealed that a committed progenitor cell population can maintain normal adult tissue in the long term without support from a stem-cell population. Here, the stem-cell theories that explain epidermal homeostasis are challenged.
Research Articles
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
Aaheli Roy Choudhury, Zhenyu Ju, Meta W Djojosubroto, Andrea Schienke, Andre Lechel, Sonja Schaetzlein, Hong Jiang, Anna Stepczynska, Chunfang Wang, Jan Buer, Han-Woong Lee, Thomas von Zglinicki, Arnold Ganser, Peter Schirmacher, Hiromitsu Nakauchi & K Lenhard Rudolph
doi:10.1038/ng1937
Nature Genetics 39, 99-105 (2007)
Epigenetic stem cell signature in cancer
Martin Widschwendter, Heidi Fiegl, Daniel Egle, Elisabeth Mueller-Holzner, Gilbert Spizzo, Christian Marth, Daniel J Weisenberger, Mihaela Campan, Joanne Young, Ian Jacobs & Peter W Laird
doi:10.1038/ng1941
Nature Genetics 39, 157-158 (2007)
The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice
Ying Liang, Michael Jansen, Bruce Aronow, Hartmut Geiger & Gary Van Zant
doi:10.1038/ng1938
Nature Genetics 39, 178-188 (2007)
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
Joyce E Ohm, Kelly M McGarvey, Xiaobing Yu, Linzhao Cheng, Kornel E Schuebel, Leslie Cope, Helai P Mohammad, Wei Chen, Vincent C Daniel, Wayne Yu, David M Berman, Thomas Jenuwein, Kevin Pruitt, Saul J Sharkis, D Neil Watkins, James G Herman & Stephen B Baylin
doi:10.1038/ng1972
Nature Genetics 39, 237-242 (2007)
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
Yangming Wang, Rostislav Medvid, Collin Melton, Rudolf Jaenisch & Robert Blelloch
doi:10.1038/ng1969
Nature Genetics 39, 380-385 (2007)
p38
MAP kinase is essential in lung stem and progenitor cell proliferation
and differentiation
Juan José Ventura, Stephan Tenbaum, Eusebio Perdiguero, Marion Huth, Carmen Guerra, Mariano Barbacid, Manolis Pasparakis & Angel R Nebreda
doi:10.1038/ng2037
Nature Genetics 39, 750-758 (2007)
Generation of germline-competent induced pluripotent stem cells
Keisuke Okita, Tomoko Ichisaka & Shinya Yamanaka
doi:10.1038/nature05934
Nature Genetics 448, 313-317 (2007)
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
Marius Wernig, Alexander Meissner, Ruth Foreman, Tobias Brambrink, Manching Ku, Konrad Hochedlinger, Bradley E. Bernstein & Rudolf Jaenisch
doi:10.1038/nature05944
Nature 448, 318-324 (2007)
New cell lines from mouse epiblast share defining features with human embryonic stem cells
Paul J. Tesar, Josh G. Chenoweth, Frances A. Brook, Timothy J. Davies, Edward P. Evans, David L. Mack, Richard L. Gardner & Ronald D. G. McKay
doi:10.1038/nature05972
Nature 448, 196-199 (2007)
Derivation of pluripotent epiblast stem cells from mammalian embryos
I. Gabrielle M. Brons, Lucy E. Smithers, Matthew W. B. Trotter, Peter Rugg-Gunn, Bowen Sun, Susana M. Chuva de Sousa Lopes, Sarah K. Howlett, Amanda Clarkson, Lars Ahrlund-Richter, Roger A. Pedersen & Ludovic Vallier
doi:10.1038/nature05950
Nature 448, 191-195 (2007)
Producing primate embryonic stem cells by somatic cell nuclear transfer
J. A. Byrne, D. A. Pedersen, L. L. Clepper, M. Nelson, W. G. Sanger, S. Gokhale, D. P. Wolf & S. M. Mitalipov
doi:10.1038/nature06357
Nature 450, 497-502 (2007)
Reprogramming of human somatic cells to pluripotency with defined factors
In-Hyun Park, Rui Zhao, Jason A. West, Akiko Yabuuchi, Hongguang Huo, Tan A. Ince, Paul H. Lerou, M. William Lensch & George Q. Daley
doi:10.1038/nature06534
Nature 451, 141-146 (2007)
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors
Marco Seandel, Daylon James, Sergey V. Shmelkov, Ilaria Falciatori, Jiyeon Kim, Sai Chavala, Douglas S. Scherr, Fan Zhang, Richard Torres, Nicholas W. Gale, George D. Yancopoulos, Andrew Murphy, David M. Valenzuela, Robin M. Hobbs, Pier Paolo Pandolfi & Shahin Rafii
doi:10.1038/nature06129
Nature 449, 346-350 (2007)
Functional skeletal muscle regeneration from differentiating embryonic stem cells
Radbod Darabi, Kimberly Gehlbach, Robert M Bachoo, Shwetha Kamath, Mitsujiro Osawa, Kristine E Kamm, Michael Kyba & Rita C R Perlingeiro
doi:10.1038/nm1705
Nature Medicine 14, 134-143 (2008)
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
Zhenyu Ju, Hong Jiang, Maike Jaworski, Chozhavendan Rathinam, Anne Gompf, Christoph Klein, Andreas Trumpp & K Lenhard Rudolph
doi:10.1038/nm1578
Nature Medicine 13, 742-747 (2007)
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease
Jean-Pyo Lee, Mylvaganam Jeyakumar, Rodolfo Gonzalez, Hiroto Takahashi, Pei-Jen Lee, Rena C Baek, Dan Clark, Heather Rose, Gerald Fu, Jonathan Clarke, Scott McKercher, Jennifer Meerloo, Franz-Josef Muller, Kook In Park, Terry D Butters, Raymond A Dwek, Philip Schwartz, Gang Tong, David Wenger, Stuart A Lipton, Thomas N Seyfried, Frances M Platt & Evan Y Snyder
doi:10.1038/nm1548
Nature Medicine 13, 439-447 (2007)
Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
Fulvio Mavilio, Graziella Pellegrini, Stefano Ferrari, Francesca Di Nunzio, Enzo Di Iorio, Alessandra Recchia, Giulietta Maruggi, Giuliana Ferrari, Elena Provasi, Chiara Bonini, Sergio Capurro, Andrea Conti, Cristina Magnoni, Alberto Giannetti & Michele De Luca
doi:10.1038/nm1504
Nature Medicine 12, 1397-1402 (2006)
Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal & Steven A Goldman
doi:10.1038/nm1495
Nature Medicine 12, 1259-1268 (2006)
Nanog maintains pluripotency of mouse embryonic stem
cells by inhibiting NF
B
and cooperating with Stat3
Josema Torres & Fiona M. Watt
doi:10.1038/ncb1680
Nature Cell Biology 10, 194-201 (2008)
Integrin-dependent anchoring of a stem-cell niche
Guy Tanentzapf, Danelle Devenport, Dorothea Godt & Nicholas H. Brown
doi:10.1038/ncb1660
Nature Cell Biology 9, 1413-1418 (2007)
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
Julie K. Stock, Sara Giadrossi, Miguel Casanova, Emily Brookes, Miguel Vidal, Haruhiko Koseki, Neil Brockdorff, Amanda G. Fisher & Ana Pombo
doi:10.1038/ncb1663
Nature Cell Biology 9, 1428-1435 (2007)
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
Shinji Masui, Yuhki Nakatake, Yayoi Toyooka, Daisuke Shimosato, Rika Yagi, Kazue Takahashi, Hitoshi Okochi, Akihiko Okuda, Ryo Matoba, Alexei A. Sharov, Minoru S. H. Ko & Hitoshi Niwa
doi:10.1038/ncb1589
Nature Cell Biology 9, 625-635 (2007)
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells
Arianna Dellavalle, Maurilio Sampaolesi, Rossana Tonlorenzi1, Enrico Tagliafico, Benedetto Sacchetti, Laura Perani, Anna Innocenzi, Beatriz G. Galvez, Graziella Messina, Roberta Morosetti, Sheng Li, Marzia Belicchi, Giuseppe Peretti, Jeffrey S. Chamberlain, Woodring E. Wright, Yvan Torrente, Stefano Ferrari, Paolo Bianco & Giulio Cossu
doi:10.1038/ncb1542
Nature Cell Biology 9, 255-267 (2007)
Niche-mediated control of human embryonic stem cell self-renewal and differentiation
Raheem Peerani, Balaji M Rao, Celine Bauwens, Ting Yin, Geoffrey A Wood, Andras Nagy, Eugenia Kumacheva and Peter W Zandstra
doi:10.1038/sj.emboj.7601896
EMBO Journal 26, 4744�4755 (2007)
Characterization of GATA-1+ hemangioblastic cells in the mouse embryo
Tomomasa Yokomizo, Satoru Takahashi, Naomi Mochizuki, Takashi Kuroha, Masatsugu Ema, Asami Wakamatsu, Ritsuko Shimizu, Osamu Ohneda, Motomi Osato, Hitoshi Okada, Toshihisa Komori, Minetaro Ogawa, Shin-Ichi Nishikawa, Yoshiaki Ito and Masayuki Yamamoto
doi:10.1038/sj.emboj.7601480
EMBO Journal 26, 184�196 (2006)
A sub-population of high proliferative potential-quiescent
human mesenchymal stem cells is under the reversible control of interferon
/
A Hatzfeld, P Eid, I Peiffer, M L Li, R Barbet, R A J Oostendorp, V Haydont, M-N Monier, L Milon, N Fortunel, P Charbord, M Tovey & J Hatzfeld
doi:10.1038/sj.leu.2404589
Leukemia 21, 714-724 (2007)
Bcl-XL modulates the differentiation of immortalized human neural stem cells
I Liste, E García-García, C Bueno & A Martínez-Serrano
doi:10.1038/sj.cdd.4402205
Cell Death and Differentiation 14, 1880-1892 (2007)
Isolation and characterization of a murine resident liver stem cell
A Conigliaro, M Colletti, C Cicchini, M T Guerra, R Manfredini, R Zini, V Bordoni, F Siepi, M Leopizzi, M Tripodi & L Amicone
doi:10.1038/sj.cdd.4402236
Cell Death and Differentiation 15, 123-133 (2008)
CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
S Ma, T K Lee, B-J Zheng, K W Chan & X-Y Guan
doi:10.1038/sj.onc.1210811
Oncogene advance online publication, 24 Sep 2007
Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice
M Galiè, G Konstantinidou, D Peroni, I Scambi, C Marchini, V Lisi, M Krampera, P Magnani, F Merigo, M Montani, F Boschi, P Marzola, R Orrù, P Farace, A Sbarbati & A Amici
doi:10.1038/sj.onc.1210920 advance online publication, 12 Nov 2007 ,
Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma
H Taubert, T Greither, D Kaushal, P Würl, M Bache, F Bartel, A Kehlen, C Lautenschläger, L Harris, K Kraemer, A Meye, M Kappler, H Schmidt, H-J Holzhausen & S Hauptmann
doi:10.1038/sj.onc.1209880
Oncogene 26, 1098-1100 (2007)
p53 homologue, p51/p63, maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity
R Okuyama, E Ogawa, H Nagoshi, M Yabuki, A Kurihara, T Terui, S Aiba, M Obinata, H Tagami & S Ikawa
doi:10.1038/sj.onc.1210235
Oncogene 26, 4478-4488 (2007)
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
L Patrawala, T Calhoun, R Schneider-Broussard, H Li, B Bhatia, S Tang, J G Reilly, D Chandra, J Zhou, K Claypool, L Coghlan & D G Tang
doi:10.1038/sj.onc.1209327
Nature Reviews Immunology 25, 1696-1708 (2006)
Inhibitory KIR–HLA receptor–ligand mismatch in autologous haematopoietic stem cell transplantation for solid tumour and lymphoma
W Leung, R Handgretinger, R Iyengar, V Turner, M S Holladay and G A Hale
doi:10.1038/sj.bjc.6603913
British Journal of Cancer 97, 539-542 (2006)
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
P Phatak, J C Cookson, F Dai, V Smith, R B Gartenhaus, M F G Stevens and A M Burger
doi:10.1038/sj.bjc.6603691
British Journal of Cancer 96, 1223-1233 (2007)
