Nature Reviews Drug Discovery
Volume 7, No 7 July 2008
Featured Article
Purinergic signalling and disorders of the central nervous system
Geoffrey Burnstock
Main pages for finding content:
2007 ISI Impact Factor 23.308(*Source of Impact Factor data)
Current Issue
News
ASCO presentations highlight value of cancer biomarkers
Alisa Opar
Which studies made a splash at this year's American Society of Clinical Oncology meeting?
Current Issue
News feature
Nurturing European collaboration
Bethan Hughes
Establishing networks that tackle issues ranging from drug development bottlenecks to manufacturing standards has become a key part of Europe's strategy to improve its global competitiveness. Bethan Hughes investigates progress so far.
ADVANCED ONLINE PUBLICATION
Review
Pseudoreceptor models in drug design: bridging ligand- and receptor-based virtual screening
Yusuf Tanrikulu & Gisbert Schneider
Pseudoreceptor models can provide a valuable tool for drug design in cases where a high–resolution structure of the target is not available. This article reviews pseudoreceptor modelling techniques, presenting recent applications in hit and lead finding, and critically discusses the prerequisites, advantages and limitations of the various approaches.
Current Issue
Research Highlights
-
Eye diseases:
Convenient leakage reduction
-
Metabolic disease:
Blocking brain enzyme curbs appetite
-
Vaccines:
Mast cells key to new vaccine adjuvants
ADVANCED ONLINE PUBLICATION
Perspective
The adult human brain in preclinical drug development
Mike Dragunow
Neuroprotective agents that slow cell death, vital for the treatment of a range of neurodegenerative disorders, are currently lacking. Dragunow discusses some of the factors contributing to the failure of translation from the laboratory to the clinic, and suggests approaches to introduce an adult human preclinical platform to overcome translation obstacles in neurodegenerative drug development.
Current issue
Careers and recruitment
Laboratory automation
Marc Feiglin and James Sterling
Automated technologies are well established as a standard component of biomedical research in industry, and are becoming increasingly common in academic institutions.
Noticeboard
SciBX: Science - Business eXchange from NPG and BioCentury
SciBX can save you time and resources by identifying and describing key translational research, identifying novel competition, and facilitating early opportunities for investment, alliances and partnerships. SciBX provides both scientific and commercial perspectives on the most important 25 scientific papers each week.
Focus on Antivirals
This joint Web Focus from Nature Reviews Drug Discovery and Nature Biotechnology hosts a collection of reviews, research highlights and commentaries covering the science and business of antiviral drug R&D. Thanks to the generous support of Pfizer (principal sponsor) and Gilead (supporting sponsor), content in the focus is freely available until June 2008.
Conferences
A selection of conferences in the field of drug discovery and development.
NPG BioPartnering site
This site is dedicated to small and large companies looking for commercial partnerships and finding out more about licensing.
Nature Reports Stem Cells
Nature Reports Stem Cells for the latest news, research, comment and analysis about stem cells and their implications.
Career snapshots
Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field.
Naturejobs spotlights and regions
Interactive regional map linking to information, features and career opportunities worldwide.
Natureevents
A comprehensive resource of information on scientific events and conferences around the world.
Journal Citation Reports, Thomson, 2007
