Early career investigator

Congratulations to Adam Frymoyer, named this issue's Early Career Investigator. Check out why he was drawn to pediatric research, who his mentors are, and his lessons learned. See page 850

Prenatal exposure to BPA increases the risk of allergic disease

Prenatal exposure to bisphenol A (BPA) has been associated with several health outcomes. In this study from China, Zhou et al. observed an association between maternal urinary concentrations of BPA and infants' allergic diseases at 6 months of age. They found an increased risk in female infants of exposed pregnancies. See page 851

BPA and phthalates associated with endothelial dysfunction

In a predominantly Mexican American and Hispanic population, Kataria et al. found that increasing urinary concentrations of bisphenol A (BPA), phthalates, and the BPA-substitute bisphenol S were associated with cardiometabolic risk factors even after correcting for body mass index. See page 857

Pharmacokinetics of high-dose erythropoietin in HIE (new ECI article!)

Erythropoietin is a promising drug in combination with cooling in the treatment of hypoxic-ischemic encephalopathy (HIE). Frymoyer et al. studied the pharmacokinetics of administered erythropoietin to develop dosing regimens that achieve target neuroprotective exposure levels. See page 865

A novel SPC mutation affects protein processing and location

Protein C mutations cause interstitial lung disease. Hong et al. studied a novel mutation that resulted in arrest of protein processing and/or excessive degradation of the proprotein. They found that the mutated protein colocalizes with ubiquitin, implying a degradation pathway other than that for wild type. See page 891

Prevention of fetal growth restriction induced cardiac dysfunction by IGF-1

Physiological and structural changes are a frequent outcome in growth-restricted infants. Alsaied et al. found that intraplacental transfer of insulin-like growth factor-1 (IGF-1) prevented cardiac dysfunction in a mouse model of fetal growth restriction. See page 919