Abstract
ABSTRACT. Milrinone may be used in the treatment of pulmonary hypertensive diseases of the newborn. We have studied its effects in chronically instrumented newborn lambs over a dose range from 1-100 jig/kg. These actions have been compared with those of amrinone. We have also tested the effect of milrinone on hypoxia and leukotriene Dj-induced pulmonary vasoconstriction. Injected into the right pulmonary artery, both amrinone and milrinone cause a dose-related fall in pulmonary arteriolar resistance with milrinone being approximately 20 times more potent than amrinone and possessing an ED50 of about 10 jig/kg. Both agents increase left ventricular dp/dt significantly and tend to increase cardiac output. Systemic vascular resistance falls with both drugs but the change is significant only with milrinone. While milrinone attenuates the increase in pulmonary arteriolar resistance induced by leukotriene D4 and hypoxia, this is probably an indirect effect. Milrinone does not modify either the increases in left atrial, aortic pressure, and systemic vascular resistance or the decreases in cardiac output and left ventricular dp/dt induced by leukotriene D4. These findings suggest that milrinone deserves clinical trial in newborn infants with pulmonary hypertension in whom myocardial depression often coexists.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Coe, J., Olley, P., Vella, G. et al. Bipyridine Derivatives Lower Arteriolar Resistance and Improve Left Ventricular Function in Newborn Lambs. Pediatr Res 22, 422–428 (1987). https://doi.org/10.1203/00006450-198710000-00012
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198710000-00012
This article is cited by
-
Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation
Intensive Care Medicine (2008)
-
Hemodynamic effects of amrinone in children after cardiac surgery
Intensive Care Medicine (1990)
-
Hemodynamic effects of amrinone in children after cardiac surgery
Intensive Care Medicine (1990)