Tissue-specific gene mutations might predispose individuals to idiopathic AF
This article has no abstract so we have provided the first paragraph of the full text.
Most molecular pathology studies of atrial fibrillation (AF) have focused on rare, familial forms of the disorder. While these analyses are likely to provide insights into the molecular pathways involved in AF, the genetic abnormalities identified might not represent the pathogenesis in more-common, nonfamilial forms of AF. In their study, Gollob et al. investigated whether idiopathic AF has a genetic basis. Since tissue-specific and somatic mutations are increasingly being identified as the cause of sporadic cases of nonmalignant disease, they also hypothesized that mutations predisposing the atria to fibrillation might be somatic in nature.
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