Can stem-cell transplantation improve cardiac function in ischemic cardiomyopathy?
Kate Matthews
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Congestive heart failure (CHF) is an important global health problem. This condition arises from myocardial dysfunction and prevents the heart from circulating sufficient blood to sustain the metabolic requirements of the body. Patel and co-workers hypothesized that autologous stem-cell transplantation to ischemic regions of the heart could regenerate cardiac myocytes and stimulate neovascularization, to restore myocardium viability and improve cardiac function, in patients undergoing off-pump coronary artery bypass grafting (OPCABG) for ischemic cardiomyopathy.
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