Review

Nature Clinical Practice Cardiovascular Medicine (2005) 2, 576-584
doi:10.1038/ncpcardio0348  
Received 25 April 2005 | Accepted 3 August 2005

Drug Insight: statins and stroke

Ralph L Sacco and James K Liao*

Correspondence *Vascular Medicine Research, Brigham & Women's Hospital, 65 Landsdowne Street, Room 275, Cambridge, MA 02139, USA

Email
 jliao@rics.bwh.harvard.edu

Statins are potent inhibitors of cholesterol synthesis and can reduce the risk of cardiovascular disease and strokes in high-risk patients. As discussed here, evidence suggests that statins, in addition to their lipid-lowering capacities, have nonlipid-mediated or pleiotropic roles in stroke prevention.

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