Review

Nature Clinical Practice Cardiovascular Medicine (2005) 2, 450-455
doi:10.1038/ncpcardio0307  
Received 11 March 2005 | Accepted 13 June 2005

Large-artery stiffness, hypertension and cardiovascular risk in older patients

Jacques Blacher and Michel E Safar*

Correspondence *Diagnosis Center, Hôpital Hôtel-Dieu, 1 Place du Parvis Notre-Dame, 75181 Paris, Cedex 04, France

Email
 michel.safar@htd.ap-hop-paris.fr

Developments in the interpretation of blood pressure curves have enabled assessment of pressure-wave reflections and arterial stiffness in the vascular system. These measurements can be translated into assessment of cardiovascular risk, enabling new features of cardiovascular disease and new drug treatments to be investigated. Here, the structural and functional factors that influence arterial stiffness are discussed.

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