Mechanisms of Disease: current understanding and future challenges in Brugada syndrome
Wataru Shimizu*, Takeshi Aiba and Shiro Kamakura
Correspondence *Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan
Email wshimizu@hsp.ncvc.go.jp
Mutations in SCN5A, the gene encoding the 
subunit of the cardiac sodium channel, are associated with a number of cardiac rhythm syndromes, including Brugada syndrome. This review discusses the genotypic and phenotypic characteristics, cellular mechanisms, diagnosis and management of Brugada syndrome.
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