HOPE-TOO results: vitamin E supplements do not protect against cancer or cardiovascular disease
This article has no abstract so we have provided the first paragraph of the full text.
Epidemiological and experimental studies have pointed to a role for vitamin E in cancer and cardiovascular disease prevention. A daily dose of this antioxidant produced no benefit, however, in the Heart Outcomes Prevention Evaluation (HOPE) trial, which randomized patients with diabetes mellitus or vascular disease to vitamin E supplementation or placebo over a median period of 4.5 years. To determine whether a benefit might be observed over the longer term, the study was extended; results from the HOPE—The Ongoing Outcomes (HOPE-TOO) trial extension have recently been published.
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