Can nicorandil treat angina pectoris effectively?
Udho Thadani
Correspondence Oklahoma University Medical Center and VA Medical Center, Cardiovascular Diseases Section, Department of Medicine/OUHSC, PO Box 26901, WP3120, Oklahoma City, OK 73190, USA
Email udho-thadani@ouhsc.edu
This article has no abstract so we have provided the first paragraph of the full text.
Chronic stable angina is a common condition that is usually caused by severe underlying narrowing of one or more coronary arteries. Severe coronary stenosis and microcirculatory disorders can limit the increase in coronary blood flow during periods of increased demand, which results in myocardial ischemia and angina pectoris. In addition to severely stenosed coronary lesions, the coronary arteries of patients who have stable angina contain many more nonobstructive plaques that are prone to rupture, resulting in acute coronary syndrome (myocardial infarction, unstable angina and sudden ischemic death). Therefore, medical management of patients with stable angina must include strategies that not only relieve angina and enable angina-free walking, but also reduce the incidence of serious adverse clinical outcomes.1, 2
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