Mechanisms of Disease: new mechanisms of antiarrhythmic actions
Robert F Gilmour Jr* and Douglas P Zipes
Correspondence *Department of Biomedical Sciences, T7 012C VRT, Cornell University, Ithaca, NY 14853, USA
Email rfg2@cornell.edu
The underlying electrophysiological mechanisms of cardiac arrhythmias remain unclear. Consequently, therapy is difficult, and for the worst arrhythmias is frequently ineffective. This review looks at the accumulating evidence for various emerging mechanisms of cardiac arrhythmias, with focus on selected ionic currents, stretch-activated phenomena and connexins.
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