Original Article

Prostate Cancer and Prostatic Diseases (2006) 9, 414–419. doi:10.1038/sj.pcan.4500874; published online 2 May 2006

Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma

D Tomas1, M Ulamec1, T Hudolin2, S Bulimbas caronic acute3, M Belicza1 and B Krus caronlin1

  1. 1Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia
  2. 2Department of Urology, Zagreb University Hospital Center, Zagreb, Croatia
  3. 3Department of Pathology, Sveti duh General Hospital, Zagreb, Croatia

Correspondence: Dr D Tomas, Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital, Vinogradska 29, 10000 Zagreb, Croatia. E-mail: dtomas@kbsm.hr

Received 25 January 2006; Revised 17 March 2006; Accepted 19 March 2006; Published online 2 May 2006.

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Abstract

The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoural tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.

Keywords:

myofibroblasts, tenascin-C, laminin, prostate adenocarcinoma

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