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Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma

Abstract

The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoural tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.

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Acknowledgements

This work was supported by grants 0108001/02 (BK) and 0134002/02 (MB) from Ministry of Science and Technology, Republic of Croatia.

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Correspondence to D Tomas.

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Tomas, D., Ulamec, M., Hudolin, T. et al. Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma. Prostate Cancer Prostatic Dis 9, 414–419 (2006). https://doi.org/10.1038/sj.pcan.4500874

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