Abstract
A major problem with the use of serum prostate-specific antigen (PSA) in predicting prostate cancer risk is the considerable variability of such measurements. Cramer et al. identified a set of single-nucleotide polymorphisms (SNPs) in the upstream regulatory region of the PSA gene that were each associated with increased promoter activity and serum PSA, further suggesting that genotyping these SNPs could be useful in improving the predictive value of PSA screening. In order to replicate this finding, DNA samples from 475 African-American men were genotyped for the same SNPs and no association was observed with either serum PSA level or prostate cancer diagnosis.
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Acknowledgements
We thank Julie McLaughlin for assistance with data analysis and Lisa Robbins for expert secretarial support. We also gratefully acknowledge support from the Department of Urology, University of Michigan Medical School; the University of Michigan Comprehensive Cancer Center Affymetrix and cDNA Microarray Core Facility; a Healthy Disparity Research Prostate Scholar Award from the Department of Defense, and the University of Michigan Prostate Cancer S.P.O.R.E. (CA069568).
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Beebe-Dimmer, J., Lange, L., Cain, J. et al. Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men. Prostate Cancer Prostatic Dis 9, 50–55 (2006). https://doi.org/10.1038/sj.pcan.4500840
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DOI: https://doi.org/10.1038/sj.pcan.4500840