¹Department of Urology, Naval Medical Center, San Diego, California, USA

Correspondence: CL Amling, Department of Urology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134-5000, USA. E-mail: clamling@nmcsd.med.navy.mil

Received 25 September 2003; Revised 27 January 2004; Accepted 6 February 2004; Published online 27 April 2004.

Abstract

In a prospective randomized study, we compare standard prostate biopsy to extensive biopsy utilizing intravenous conscious sedation (IVCS). Initial biopsy patients (n=197) were randomized to either standard biopsy using intrarectal lidocaine gel (6–12 biopsies, mean 10.1) or extensive biopsy (24 biopsies) using IVCS. Cancer detection and urinary symptoms were no different between groups. However, biopsy pain was rated significantly lower and satisfaction significantly higher in the extensive biopsy group. Temporary urinary retention occurred in 4% of the extensive biopsy group. Extended biopsy with 24 samples does not improve cancer detection compared to standard biopsy when 10 cores are obtained. Extensive biopsy is very well tolerated and associated with less pain and more satisfaction than standard biopsy.