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| Paper |
| A Nod Scid mouse model to study human prostate cancer |
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| C Bastide1, C Bagnis2, P Mannoni2, J Hassoun3 and F Bladou1 |
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1Service d'Urologie, Pr Serment, Hôpital Salvator, Marseille, France
2Centre de Thérapie Génique, Institut Paoli-Calmettes, Marseille, France
3Laboratoire d'Anatomopathologie, Institut Paoli-Calmettes, Marseille, France
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Correspondence to: F Bladou, Hôpital Salvator, 249 Bd de Sainte Marguerite, 13274 Marseille, cedex 9 France. E-mail: fbladou@mail.ap-hm.fr |
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| Abstract |
| Prostate cancer is the second cause of cancer mortality in men in Western countries. To study new therapeutic approaches such as gene therapy, animal models of human prostate cancer with metastatic behavior are mandatory. We used the Nod Scid mouse strain to develop an orthotopic animal model. Two androgen-independent cell lines (PC-3 and DU 145) were used. Local tumor growth and metastases were analyzed. The tumor take rates were close to those reported in the literature. However, a high frequency of various metastatic sites has been observed (liver, lung, spleen, adrenal, kidney, lymph node, and diaphragm). It can be concluded that the Nod Scid mouse is a relevant preclinical animal model to study human prostate cancer. Metastatic sites seem more numerous in comparison to other orthotopic mice models described. Prostate Cancer and Prostatic Diseases (2002) 5, 311-315. doi:10.1038/sj.pcan.04500606 |
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| Keywords |
| Nod Scid mouse; orthotopic implantation; metastases; prostate cancer; animal model |
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| Received 24 January 2002; revised 2 May 2002; accepted 21 May 2002 |
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| December 2002, Volume 5, Number 4, Pages 311-315 |
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