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Clinical Research

The association between race and treatment regret among men with recurrent prostate cancer

Prostate Cancer and Prostatic Diseases volume 18, pages 38–42 (2015)Cite this article

Subjects

Abstract

Background:

To examine the impact of race on treatment regret among men with recurrent prostate cancer after surgery or radiation.

Methods:

The prospective Comprehensive, Observational, Multicenter, Prostate Adenocarcinoma (COMPARE) registry was used to study a cohort of 484 men with biochemically recurrent prostate cancer after radical prostatectomy, external beam radiation or brachytherapy. Multivariable logistic regression was used to model the association between race and treatment regret and to determine whether there was an interaction between race and sexual problems after treatment with regards to treatment regret.

Results:

Black men (N=78) were significantly more likely to have treatment regret when compared with non-black men (N=406; 21.8% versus 12.6%) on univariable analysis (odds ratio (OR) 1.94; 95% confidence interval 1.05–3.56; P=0.03). On multivariable analysis, black race trended towards but was no longer significantly associated with an increase in treatment regret (adjusted OR (AOR) 1.84 (0.95–3.58); P=0.071). There was an interaction between race and sexual problems after treatment (Pinteraction=0.02) such that among those without sexual problems, black men had more treatment regret than non-black men (26.7% versus 8.4%: AOR 4.68 (1.73–12.63); P=0.002), whereas among those with sexual problems, there was no difference in treatment regret between black and non-black men (18.8% versus 17.3%: AOR 1.04 (0.44–2.46); P=0.93).

Conclusions:

Among men with recurrent prostate cancer after surgery or radiation, black men were nearly twice as likely to experience treatment regret. Treating physicians should ensure that patients are fully apprised of the pros and cons of all treatment options to reduce the risk of subsequent regret.

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Acknowledgements

This work is supported by David and Cynthia Chapin, the Prostate Cancer Foundation, Fitz’s Cancer Warriors, Hugh Simons in honor of Frank and Anne Simons and a grant from an anonymous family foundation.

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Authors and Affiliations

  1. Harvard Medical School, Boston, MA, USA

    B A Mahal

  2. Department of Statistics, University of Connecticut, Storrs, CT, USA

    M-H Chen

  3. South Carolina College of Pharmacy, Hollings Cancer Center, Charleston, SC, USA

    C L Bennett

  4. Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA

    M W Kattan

  5. Department of Medicine and Urology, Tulane University, New Orleans, LA, USA

    O Sartor

  6. Novartis, East Hanover, NJ, USA

    K Stein

  7. Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    A V D'Amico & P L Nguyen

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Correspondence to P L Nguyen.

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Mahal, B., Chen, MH., Bennett, C. et al. The association between race and treatment regret among men with recurrent prostate cancer. Prostate Cancer Prostatic Dis 18, 38–42 (2015). https://doi.org/10.1038/pcan.2014.42

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