Prostate Cancer and Prostatic Diseases

FIGURE 3

FROM:

ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification

B Furusato, S-H Tan, D Young, A Dobi, C Sun, A A Mohamed, R Thangapazham, Y Chen, G McMaster, T Sreenath, G Petrovics, D G McLeod, S Srivastava and I A Sesterhenn

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Figure 3.

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ERG oncoprotein in carcinoma with heterogeneous expression and non-discriminatory staining of benign glands. (a) Tumor shows a ‘diverse’ ERG expression pattern with ERG positive alternating with ERG negative clones, H&E × 20. (b) Same field as (a). Although, the tumor cells appear similar in the H&E-stained section, they differ in their ERG oncoprotein distribution, ERG–MAb × 20. (c) Benign gland with basal and secretory cells, H&E × 20. (d) Same field as (c). The nuclei of the secretory and basal cells are negative for ERG. Note weak cytoplasmic reactivity in the secretory cells. The endothelial cells show strong nuclear positivity for ERG, ERG–MAb × 20.

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