1. ¹Department of Nuclear Medicine, University of Bonn, Bonn, Germany
2. ²Department of Radiology, University of Bonn, Bonn, Germany
3. ³Gemeinschaftspraxis für Radiologie und Nuklearmedizin, Siegburg, Germany

Correspondence: Dr J Bucerius, Department of Nuclear Medicine, University of Bonn, Sigmund-Freud-Str. 25, Bonn 53105, Germany. E-mail: jan.bucerius@ukb.uni-bonn.de

Received 10 August 2006; Revised 12 January 2007; Accepted 17 January 2007; Published online 13 March 2007.

Abstract

Diagnosis of prostate cancer (PC) still remains critical as non-invasive screening with prostate specific-antigen (PSA) lacks to indicate malignancy of the prostate in some cases. Recent research has shown that clinically meaningful PC can develop in patients with a PSA value <4 ng/ml, frequently defined as upper limit of normal serum PSA levels. Furthermore, both morphological (computed tomography (CT), magnetic resonance imaging, transrectal ultrasound) and functional imaging with ¹⁸fluorodeoxyglucose positron emission tomography (FDG-PET) are associated with several limitations for primary diagnosis of PC. We report a case of an incidentally diagnosed PSA-negative PC by ¹⁸FDG PET/CT in a patient with a previous diagnosis of a hypopharyngeal cancer.