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Cancer & Metabolism

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Review articles

Understanding cachexia as a cancer metabolism syndrome

P E Porporato

Oncogenesis (2016) 5, e200; doi:10.1038/oncsis.2016.3 Published online 22 February 2016

Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer

R J Klement and M K Fink

Oncogenesis (2016) 5, e193; doi:10.1038/oncsis.2016.2 Published online 15 February 2016

Energy disruptors: rising stars in anticancer therapy?

F Bost, A-G Decoux-Poullot, J F Tanti and S Clavel

Oncogenesis (2016) 5, e188; doi:10.1038/oncsis.2015.46 Published online 18 January 2016

Hypoxia and metabolic adaptation of cancer cells

K L Eales, K E R Hollinshead and D A Tennant

Oncogenesis (2016) 5, e190; doi:10.1038/oncsis.2015.50 Published online 25 January 2016

Lipid metabolic reprogramming in cancer cells

S Beloribi-Djefaflia, S Vasseur and F Guillaumond

Oncogenesis (2016) 5, e189; doi:10.1038/oncsis.2015.49 Published online 25 January 2016

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Relevant articles from Oncogenesis

Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer

J Yang, J Wei, Y Wu, Z Wang, Y Guo, P Lee and X Li

Oncogenesis (2015) 4: e158; doi: 10.1038/oncsis.2015.18; published online 15 June 2015

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

P Torres-Ayuso1, M Tello-Lafoz1, I Mérida1 and A Ávila-Flores

Oncogenesis (2015) 4: e164; doi: 10.1038/oncsis.2015.22; published online 24 August 2015

Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells

A Herrmann, M Rice, R Lévy, B L Pizer, P D Losty, D Moss and V Sée

Oncogenesis (2015) 4, e138; doi:10.1038/oncsis.2014.52; Published online 9 February 2015

Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a production

W Wang, N Snyder, A J Worth, I A Blair, and E S Witze

Oncogenesis (2015) 4, e154; doi:10.1038/oncsis.2015.15; Published online 1 June 2015

Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties

X He, A D Arslan, T-T Ho, C Yuan, M R Stampfer and W T Beck

Oncogenesis (2014) 3, e84; doi:10.1038/oncsis.2013.47; Published online 13 January 2014

PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

S N Payne, M E Maher, N H Tran, D R Van De Hey, T M Foley, A E Yueh, A A Leystra, C A Pasch, J J Jeffrey, L Clipson, K A Matkowskyj, and D A Deming

Oncogenesis (2015) 4, e169; doi:10.1038/oncsis.2015.28; Published online 5 October 2015

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

S J Allison, J R P Knight, C Granchi, R Rani, F Minutolo, J Milner and R M Phillips

Oncogenesis (2014) 3, e102; doi:10.1038/oncsis.2014.16; Published online 12 May 2014

Regulation of the pentose phosphate pathway by an androgen receptor´┐ŻmTOR-mediated mechanism and its role in prostate cancer cell growth

E Tsouko, A S Khan, M A White, J J Han, Y Shi, F A Merchant, M A Sharpe, L Xin, and D E Frigo

Oncogenesis (2014) 3, e103; doi:10.1038/oncsis.2014.18; Published online 26 May 2014

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

P Torres-Ayuso1, M Tello-Lafoz1, I Mérida1 and A Ávila-Flores

Oncogenesis (2015) 4, e164; doi:10.1038/oncsis.2015.22; Published online 24 August 2015

Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1

L V Rhodes, C R Tate, V T Hoang, H E Burks, D Gilliam, E C Martin, S Elliott, D B Miller, A Buechlein, D Rusch, H Tang, K P Nephew, M E Burow and B M Collins-Burow

Oncogenesis (2015) 4, e168; doi:10.1038/oncsis.2015.27; Published online 5 October 2015

Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation

F-f Song, L-l Xia, P Ji, Y-b Tang, Z-m Huang, L Zhu, J Zhang, J-q Wang, G-p Zhao, H-l Ge, Y Zhang and Y Wang

Oncogenesis (2015) 4, e159; doi:10.1038/oncsis.2015.10; Published online 15 June 2015

Atlas of Cancer Signalling Network: a systems biology resource for integrative analysis of cancer data with Google Maps

I Kuperstein, E Bonnet, H-A Nguyen, D Cohen, E Viara, L Grieco, S Fourquet, L Calzone, C Russo, M Kondratova, M Dutreix, E Barillot, and A Zinovyev

Oncogenesis (2015) 4, e160; doi:10.1038/oncsis.2015.19; Published online 20 July 2015

Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers

M Sánchez-Aragó, L Formentini, I Martínez-Reyes, J García-Bermudez, F Santacatterina, L Sánchez-Cenizo, I M Willers, M Aldea, L Nájera, Á Juarránz, E C López, J Clofent, C Navarro, E Espinosa and J M Cuezva

Oncogenesis (2013) 2, e46; doi:10.1038/oncsis.2013.9; Published online 22 April 2013

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Relevant articles from Oncogene

NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer

S M Hong, C W Park, S W Kim, Y J Nam, J H Yu, J H Shin, C H Yun, S-H Im, K-T Kim, Y C Sung and K Y Choi

Oncogene advance online publication 16 November 2015; doi: 10.1038/onc.2015.415

Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression

M Rodriguez, S Siwko, L Zeng, J Li, Z Yi and M Liu

Oncogene advance online publication 1 June 2015; doi: 10.1038/onc.2015.170

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening

A M Strohecker, S Joshi1, R Possemato, R T Abraham, D M Sabatini and E White

Oncogene (2015) 34, 5662-5676; doi:10.1038/onc.2015.23; published online 16 March 2015

Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

M Bonora, M R Wieckowski, C Chinopoulos, O Kepp, G Kroemer, L Galluzzi and P Pinton

Oncogene (2015) 34, 1475-1486; doi:10.1038/onc.2014.96; published online 14 April 2014

Differential effects of AMPK agonists on cell growth and metabolism

E E Vincent, P P Coelho, J Blagih, T Griss, B Viollet and R G Jones

Oncogene (2015) 34, 3627-3639; doi:10.1038/onc.2014.301; published online 22 September 2014

Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells

C Koufaris, G N Valbuena, Y Pomyen, G D Tredwell, E Nevedomskaya, C-HE Lau, T Yang, A Benito, J K Ellis and H C Keun

Oncogene advance online publication 19 October 2015; doi: 10.1038/onc.2015.333

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

M van Geldermalsen, Q Wang, R Nagarajah, A D Marshall, A Thoeng, D Gao, W Ritchie, Y Feng, C G Bailey, N Deng, K Harvey, J M Beith, C I Selinger, S A O'Toole, J E J Rasko and J Holst

Oncogene advance online publication 12 October 2015; doi: 10.1038/onc.2015.381

PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model

J Du, M Yang, S Chen, D Li, Z Chang and Z Dong

Oncogene advance online publication 12 October 2015; doi: 10.1038/onc.2015.393

Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters

L Gan, R Xiu, P Ren, M Yue, H Su, G Guo, D Xiao, J Yu, H Jiang, H Liu, G Hu and G Qing

Oncogene advance online publication 5 October 2015; doi: 10.1038/onc.2015.360

Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death

E Salas, S Roy, T Marsh, B Rubin and J Debnath

Oncogene advance online publication 5 October 2015; doi: 10.1038/onc.2015.348

PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer

S-J Fan, C Snell, H Turley, J-L Li, R McCormick, S M W Perera, S Heublein, S Kazi, A Azad, C Wilson, A L Harris and D C I Goberdhan

Oncogene advance online publication 5 October 2015; doi: 10.1038/onc.2015.363

Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation

C F de la Cruz-Herrera, M Baz-Martínez, V Lang, A El Motiam, J Barbazán, R Couceiro, M Abal, A Vidal, M Esteban, C Muñoz-Fontela, A Nieto, M S Rodríguez, M Collado and C Rivas

Oncogene advance online publication 28 September 2015; doi: 10.1038/onc.2015.356

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells

S Calabretta, P Bielli, I Passacantilli, E Pilozzi, V Fendrich, G Capurso, G Delle Fave and C Sette

Oncogene advance online publication 3 August 2015; doi: 10.1038/onc.2015.270

p54nrb/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A

Z Zhu, X Zhao, L Zhao, H Yang, L Liu, J Li, J Wu, F Yang, G Huang and J Liu

Oncogene advance online publication 6 July 2015; doi: 10.1038/onc.2015.197

Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming

S Srinivasan, M Guha, D W Dong, K A Whelan, G Ruthel, Y Uchikado, S Natsugoe, H Nakagawa and N G Avadhani

Oncogene advance online publication 6 July 2015; doi: 10.1038/onc.2015.227

BIRC5/Survivin as a target for glycolysis inhibition in high-stage neuroblastoma

J Hagenbuchner, U Kiechl-Kohlendorfer, P Obexer and M J Ausserlechner

Oncogene advance online publication 6 July 2015; doi: 10.1038/onc.2015.264

Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis

J Zhang, Q Gao, Y Zhou, U Dier, N Hempel and S N Hochwald

Oncogene advance online publication 29 June 2015; doi: 10.1038/onc.2015.256

LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells

Y M Whang, S I Park, I A Trenary, R A Egnatchik, J P Fessel, J M Kaufman, D P Carbone and J D Young

Oncogene advance online publication 29 June 2015; doi: 10.1038/onc.2015.140

Heat-shock factor 2 is a suppressor of prostate cancer invasion

J K Björk, M Åkerfelt, J Joutsen, M C Puustinen, F Cheng, L Sistonen and M Nees

Oncogene advance online publication 29 June 2015; doi: 10.1038/onc.2015.241

Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

W-B Tsai, Y Long, J-R Park, J T Chang, H Liu, J Rodriguez-Canales, N Savaraj, L G Feun, M A Davies, I I Wistuba and M T Kuo

Oncogene advance online publication 22 June 2015; doi: 10.1038/onc.2015.237

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