ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
November 16 2009 |
November 9 2009 |
November 2 2009 |
October 26 2009 |
October 19 2009 |
October 12 2009 |
October 5 2009 |
September 28 2009 |
September 21 2009 |
September 14 2009 |
September 7 2009
November 23 2009
Reviews
Activation of the hedgehog-signaling pathway in human cancer and the clinical implications
L Yang, G Xie, Q Fan and J Xie
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.392
The microRNA network and tumor metastasis
H Zhang, Y Li and M Lai
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.406
Original Articles
Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer
B Y Ahn, D L N Trinh, L D Zajchowski, B Lee, A N Elwi and S -W Kim
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.413
The tumor suppressor ING3 is degraded by SCFSkp2-mediated ubiquitin–proteasome system
G Chen, Y Wang, M Garate, J Zhou and G Li
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.424
Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome
L M Cockrell, M C Puckett, E H Goldman, F R Khuri and H Fu
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.382
Caspase 2-mediated tumor suppression involves survivin gene silencing
M Guha, F Xia, C M Raskett and D C Altieri
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.428
Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling
S Guilmeau, M Flandez, J M Mariadason and L H Augenlicht
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.393
Mesenchymal–epithelial transition in epithelial response to injury: the role of Foxc2
C Hader, A Marlier and L Cantley
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.397
Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway
J O Humtsoe and R H Kramer
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.419
Transcriptional induction of MMP-10 by TGF-
, mediated by activation of MEF2A and downregulation of class IIa HDACs
F Ishikawa, H Miyoshi, K Nose and M Shibanuma
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.387
Fhit regulates invasion of lung tumor cells
A Joannes, A Bonnomet, S Bindels, M Polette, C Gilles, H Burlet, J Cutrona, J-M Zahm, P Birembaut and B Nawrocki-Raby
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.418
Ras-induced invasion and metastasis are regulated by a leukotriene B4 receptor BLT2-linked pathway
E-Y Kim, J-M Seo, K-J Cho and J-H Kim
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.412
Ezrin is a negative regulator of death receptor-induced apoptosis
W-C Kuo, K-T Yang, S-L Hsieh and M-Z Lai
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.417
Transcriptome profiling of a TGF--induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies
A E G Lenferink, C Cantin, A Nantel, E Wang, Y Durocher, M Banville, B Paul-Roc, A Marcil, M R Wilson and M D O'Connor-McCourt
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.399
Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis
K Levanon, V Ng, H Y Piao, Yi Zhang, M C Chang, M H Roh, D W Kindelberger, M S Hirsch, C P Crum, J A Marto and R Drapkin
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.402
Adenosine A1 receptor, a target and regulator of estrogen receptor
action, mediates the proliferative effects of estradiol in breast cancer
Z Lin, P Yin, S Reierstad, M O'Halloran, J S Coon V, E K Pearson, G M Mutlu and S E Bulun
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.409
c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells
A Madeo, M Vinciguerra, R Lappano, M Galgani, A Gasperi- Campani, M Maggiolini and A M Musti
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.400
Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1
M Osanai, N Sawada and G -H Lee
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.414
Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis
E Peuhu, A Rivero-Müller, H Stykki, E Torvaldson, T Holmbom, P Eklund, M Unkila, R Sjöholm and J E Eriksson
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.386
p53-dependent senescence delays E
-myc-induced B-cell lymphomagenesis
S M Post, A Quintás-Cardama, T Terzian, C Smith, C M Eischen and G Lozano
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.423
Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
V Ramakrishnan, M Timm, J L Haug, T K Kimlinger, L E Wellik, T E Witzig, S V Rajkumar, A A Adjei and S Kumar
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.403
Rictor is a novel target of p70 S6 kinase-1
C Treins, P H Warne, M A Magnuson, M Pende and J Downward
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.401
Embryoid body formation of human amniotic fluid stem cells depends on mTOR
A Valli, M Rosner, C Fuchs, N Siegel, C E Bishop, H Dolznig, U Mädel, W Feichtinger, A Atala and M Hengstschläger
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.405
A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy
Y Watanabe, T Kojima, S Kagawa, F Uno, Y Hashimoto, S Kyo, H Mizuguchi, N Tanaka, H Kawamura, D Ichimaru, Y Urata and T Fujiwara
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.415
Knockdown of peroxisome proliferator-activated receptor- induces less differentiation and enhances cell–fibronectin adhesion of colon cancer cells
L Yang, B Olsson, D Pfeifer, J -I Jönsson, Z -G Zhou, X Jiang, B -A Fredriksson, H Zhang and X -F Sun
Oncogene advance online publication, November 23, 2009; doi:10.1038/onc.2009.370
November 16 2009
Original Articles
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions
J Akech, J J Wixted, K Bedard, M van der Deen, S Hussain, T A Guise, A J van Wijnen, J L Stein, L R Languino, D C Altieri, J Pratap, E Keller, G S Stein and J B Lian
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.389
FLASH degradation in response to UV-C results in histone locus bodies disruption and cell-cycle arrest
L Bongiorno-Borbone, A De Cola, D Barcaroli, R A Knight, C Di Ilio, G Melino and V De Laurenzi
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.388
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN
L Davidson, H Maccario, N M Perera, X Yang, L Spinelli, P Tibarewal, B Glancy, A Gray, C J Weijer, C P Downes and N R Leslie
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.384
ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo
M E Dujka, N Puebla-Osorio, O Tavana, M Sang and C Zhu
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.394
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer
N Khodarev, R Ahmad, H Rajabi, S Pitroda, T Kufe, C McClary, M D Joshi, D MacDermed, R Weichselbaum and D Kufe
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.391
Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor
Y Lu, P Liu, M James, H G Vikis, H Liu, W Wen, A Franklin and M You
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.396
Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3
C Meunier, J Cai, A Fortin, T Kwan, J -F Marquis, C Turbide, L Van Der Kraak, S Jothy, N Beauchemin and P Gros
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.369
miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors
M S Ostenfeld, J B Bramsen, P Lamy, S B Villadsen, N Fristrup, K D Sørensen, B Ulhøi, M Borre, J Kjems, L Dyrskjøt and T F Ørntoft
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.395
Activity and cellular localization of an oncogenic glioblastoma multiforme-associated EGF receptor mutant possessing a duplicated kinase domain
B H Ozer, G J Wiepz and P J Bertics
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.385
Short Communications
Enhanced mRNA cap methylation increases Cyclin D1 expression and promotes cell transformation
V H Cowling
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.368
Predicting the site of origin of tumors by a gene expression signature derived from normal tissues
E Staub, H -J Buhr and J Gröne
Oncogene advance online publication, November 16, 2009; doi:10.1038/onc.2009.398
November 9 2009
Original Articles
Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling
A H Beck, C-H Lee, D M Witten, B C Gleason, B Edris, I Espinosa, S Zhu, R Li, K D Montgomery, R J Marinelli, R Tibshirani, T Hastie, D M Jablons, B P Rubin, C D Fletcher, R B West and M van de Rijn
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.381
Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses
U-A Bommer, C Heng, A Perrin, P Dash, S Lobov, A Elia and M J Clemens
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.380
Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression
M K El-Tanani, D Jin, F C Campbell and P G Johnston
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.379
Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q
M Fischer, T Bauer, A Oberthür, B Hero, J Theissen, M Ehrich, R Spitz, R Eils, F Westermann, B Brors, R König and F Berthold
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.390
ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation
L Miao, Z Song, L Jin, Y M Zhu, L P Wen and M Wu
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.372
Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
S J Miller, Z D Lan, A Hardiman, J Wu, J J Kordich, D M Patmore, R S Hegde, T P Cripe, J A Cancelas, M H Collins and N Ratner
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.360
A 'DNA replication' signature of progression and negative outcome in colorectal cancer
M-J Pillaire, J Selves, K Gordien, P-A Gouraud, C Gentil, M Danjoux, C Do, V Negre, A Bieth, R Guimbaud, D Trouche, P Pasero, M Méchali, J-S Hoffmann and C Cazaux
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.378
Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis
C V Reeves, J Dufraine, J A T Young and J Kitajewski
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.383
Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells
A S Ribeiro, A Albergaria, B Sousa, A L Correia, M Bracke, R Seruca, F C Schmitt and J Paredes
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.338
Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice
X Xu, B Ehdaie, N Ohara, T Yoshino and C -X Deng
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.375
C/EBP redirects androgen receptor signaling through a unique bimodal interaction
J Zhang, M Gonit, M D Salazar, A Shatnawi, L Shemshedini, R Trumbly and M Ratnam
Oncogene advance online publication, November 9, 2009; doi:10.1038/onc.2009.373
November 2 2009
Review
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
R J DeBerardinis and T Cheng
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.358
Original Articles
BAG-1 overexpression attenuates luminal apoptosis in MCF-10A mammary epithelial cells through enhanced RAF-1 activation
L R Anderson, R L Sutherland and A J Butt
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.362
Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions
P-C Chan, J N Sudhakar, C-C Lai and H-C Chen
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.363
Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim
J Konishi, F Yi, X Chen, H Vo, D P Carbone and T P Dang
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.366
Chromosomal rearrangements after ex vivo Epstein–Barr virus (EBV) infection of human B cells
S Lacoste, E Wiechec, A G dos Santos Silva, A Guffei, G Williams, M Lowbeer, K Benedek, M Henriksson, G Klein and S Mai
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.359
Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition
A Lakshmikuttyamma, S A Scott, J F DeCoteau and C R Geyer
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.361
Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis
X Liu, X Wang, J Zhang, E K Y Lam, V Y Shin, A S L Cheng, J Yu, F K L Chan, J J Y Sung and H C Jin
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.332
A common gain of function of p53 cancer mutants in inducing genetic instability
D P Liu, H Song and Y Xu
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.376
Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-
1-driven activation of mTOR/p70S6-kinase pathway
B Markova, C Albers, F Breitenbuecher, J V Melo, T H Brümmendorf, F Heidel, D Lipka, J Duyster, C Huber and T Fischer
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.374
UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes
M Ming, W Han, J Maddox, K Soltani, C R Shea, D M Freeman and Y -Y He
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.357
LIM-kinase 2, a regulator of actin dynamics, is involved in mitotic spindle integrity and sensitivity to microtubule-destabilizing drugs
S T Po'uha, M S Y Shum, A Goebel, O Bernard and M Kavallaris
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.367
c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma
H Scheller, S Tobollik, A Kutzera, M Eder, J Unterlehberg, I Pfeil and B Jungnickel
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.377
Immunogenic death of colon cancer cells treated with oxaliplatin
A Tesniere, F Schlemmer, V Boige, O Kepp, I Martins, F Ghiringhelli, L Aymeric, M Michaud, L Apetoh, L Barault, J Mendiboure, J-P Pignon, V Jooste, P van Endert, M Ducreux, L Zitvogel, F Piard and G Kroemer
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.356
Wnt signaling activation and mammary gland hyperplasia in MMTV–LRP6 transgenic mice: implication for breast cancer tumorigenesis
J Zhang, Y Li, Q Liu, W Lu and G Bu
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.339
Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells
K Zhu, K Dunner Jr and D J McConkey
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.343
Short Communications
Focal amplification and oncogene dependency of GAB2 in breast cancer
M Bocanegra, A Bergamaschi, Y H Kim, M A Miller, A B Rajput, J Kao, A Langerød, W Han, D -Y Noh, S S Jeffrey, D G Huntsman, A -L Børresen-Dale and J R Pollack
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.364
HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability
M Krishnan, A B Singh, J J Smith, A Sharma, X Chen, S Eschrich, T J Yeatman, R D Beauchamp and P Dhawan
Oncogene advance online publication, November 2, 2009; doi:10.1038/onc.2009.324
October 26 2009
Review
Histone deacetylases and the immunological network: implications in cancer and inflammation
A Villagra, E M Sotomayor and E Seto
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.334
Original Articles
Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation
Y Aylon, N Yabuta, H Besserglick, Y Buganim, V Rotter, H Nojima and M Oren
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.270
Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth
S Chandarlapaty, M Scaltriti, P Angelini, Q Ye, M Guzman, C A Hudis, L Norton, D B Solit, J Arribas, J Baselga and N Rosen
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.337
Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species
J -J Lee, J -H Lee, Y -G Ko, S I Hong and J -S Lee
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.355
Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis
H Lemjabbar-Alaoui, A van Zante, M S Singer, Q Xue, Y -Q Wang, D Tsay, B He, D M Jablons and S D Rosen
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.365
Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis
C Puri, M V Chibalina, S D Arden, A J Kruppa, J Kendrick-Jones and F Buss
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.328
Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation
J P Robinson, M W VanBrocklin, A R Guilbeault, D L Signorelli, S Brandner and S L Holmen
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.333
Serum protein signature may improve detection of ductal carcinoma in situ of the breast
J Solassol, P Rouanet, P J Lamy, C Allal, G Favre, T Maudelonde and A Mangé
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.341
Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway
N H Thoennissen, J O'Kelly, D Lu, G B Iwanski, D T La, S Abbassi, A Leiter, B Karlan, R Mehta and H P Koeffler
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.335
Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling
A Yalcin, B Clem, S Makoni, A Clem, K Nelson, J Thornburg, D Siow, A N Lane, S E Brock, U Goswami, J W Eaton, S Telang and J Chesney
Oncogene advance online publication, October 26, 2009; doi:10.1038/onc.2009.317
October 19 2009
Original Articles
MdmX is a substrate for the deubiquitinating enzyme USP2a
N Allende-Vega, A Sparks, D P Lane and M K Saville
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.330
Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing
S B Cohen, W Ma, V A Valova, M Algie, R Harfoot, A G Woolley, P J Robinson and A W Braithwaite
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.321
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling
A B Hanker, N Mitin, R S Wilder, E P Henske, F Tamanoi, A D Cox and C J Der
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.336
Notch-1 activates estrogen receptor--dependent transcription via IKK in breast cancer cells
L Hao, P Rizzo, C Osipo, A Pannuti, D Wyatt, L W-K Cheung, G Sonenshein, B A Osborne and L Miele
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.323
Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-
B activity in hypoxic tumor cells
G -Y Jang, J -H Jeon, S -Y Cho, D -M Shin, C -W Kim, E M Jeong, H C Bae, T W Kim, S -H Lee, Y Choi, D -S Lee, S -C Park and I -G Kim
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.342
The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer
A Mira, C Isella, T Renzulli, D Cantarella, M L Martelli and E Medico
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.296
RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1
C A Reed, C N Mayhew, A K McClendon, X Yang, A Witkiewicz and E S Knudsen
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.303
Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery
F J Rodríguez-Ubreva, A E Cariaga-Martinez, M A Cortés, M Romero-De Pablos, S Ropero, P López-Ruiz and B Colás
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.329
The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival
D Sachdev, X Zhang, I Matise, M Gaillard-Kelly and D Yee
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.316
The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells
M N Thobe, D Gurusamy, P Pathrose and S E Waltz
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.331
Roles of PKC isoforms in the induction of apoptosis elicited by aberrant Ras
T Zhu, T Tsuji and C Chen
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.344
Short Communications
DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2
E Bourke, J A L Brown, S Takeda, H Hochegger and C G Morrison
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.340
The Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas
K B L Lin, P Tan, S A Freeman, M Lam, K M McNagny and M R Gold
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.345
Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy
J Yang, J Parsons, N H Nicolay, S Caporali, C F Harrington, R Singh, D Finch, S D'Atri, P B Farmer, P G Johnston, W G McKenna, G Dianov and R A Sharma
Oncogene advance online publication, October 19, 2009; doi:10.1038/onc.2009.327
October 12 2009
Review
The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression
R Wäsch, J A Robbins and F R Cross
Oncogene advance online publication, October 12, 2009; doi:10.1038/onc.2009.325
Original Articles
Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity
A V Lucs, W J Muller and S K Muthuswamy
Oncogene advance online publication, October 12, 2009; doi:10.1038/onc.2009.312
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage
P P Provenzano, D R Inman, K W Eliceiri and P J Keely
Oncogene advance online publication, October 12, 2009; doi:10.1038/onc.2009.299
Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53
F Su, L E Pascal, W Xiao and Z Wang
Oncogene advance online publication, October 12, 2009; doi:10.1038/onc.2009.326
TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer
M Szajnik, M J Szczepanski, M Czystowska, E Elishaev, M Mandapathil, E Nowak-Markwitz, M Spaczynski and T L Whiteside
Oncogene advance online publication, October 12, 2009; doi:10.1038/onc.2009.289
October 5 2009
Original Articles
Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein FREE
M R Abedini, E J Muller, R Bergeron, D A Gray and B K Tsang
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.300
Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation
E Borbone, M T Berlingieri, F De Bellis, A Nebbioso, G Chiappetta, A Mai, L Altucci and A Fusco
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.306
Modeling the effect of the RB tumor suppressor on disease progression: dependence on oncogene network and cellular context FREE
J L Dean, A K McClendon, K R Stengel and E S Knudsen
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.313
c-Kit mutants require hypoxia-inducible factor 1 to transform melanocytes
G Monsel, N Ortonne, M Bagot, A Bensussan and N Dumaz
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.320
Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells
P Nirdé, D Derocq, M Maynadier, M Chambon, I Basile, M Gary-Bobo and M Garcia
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.311
Cytokine expression and signaling in drug-induced cellular senescence
Z Novakova, S Hubackova, M Kosar, L Janderova-Rossmeislova, J Dobrovolna, P Vasicova, M Vancurova, Z Horejsi, P Hozak, J Bartek and Z Hodny
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.318
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
M P O'Connell, J L Fiori, M Xu, A D Carter, B P Frank, T C Camilli, A D French, S K Dissanayake, F E Indig, M Bernier, D D Taub, S M Hewitt and A T Weeraratna
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.305
SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue
C Peña, J M García, M J Larriba, R Barderas, I Gómez, M Herrera, V García, J Silva, G Domínguez, R Rodríguez, J Cuevas, A G de Herreros, J I Casal, A Muñoz and F Bonilla
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.285
Castration resistance of prostate cancer cells caused by castration-induced oxidative stress through Twist1 and androgen receptor overexpression
M Shiota, A Yokomizo, Y Tada, J Inokuchi, E Kashiwagi, D Masubuchi, M Eto, T Uchiumi and S Naito
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.322
RalA suppresses early stages of Ras-induced squamous cell carcinoma progression
A G Sowalsky, A Alt-Holland, Y Shamis, J A Garlick and L A Feig
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.307
HEY1 Leu94Met gene polymorphism dramatically modifies its biological functions
M A Villaronga, D N Lavery, C L Bevan, S Llanos and B Belandia
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.309
Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin
I Wolf, Y Laitman, T Rubinek, L Abramovitz, I Novikov, R Beeri, M Kuro-O, H P Koeffler, R Catane, L S Freedman, E Levy-Lahad, B Y Karlan, E Friedman and B Kaufman
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.301
Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin–proteasome pathway
Y Yoo, H J Ho, C Wang and J -L Guan
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.319
Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways
R van Amerongen, M C Nawijn, J -P Lambooij, N Proost, J Jonkers and A Berns
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.310
Short Communication
AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K
J M Askham, F Platt, P A Chambers, H Snowden, C F Taylor and M A Knowles
Oncogene advance online publication, October 5, 2009; doi:10.1038/onc.2009.315
September 28 2009
Original Articles
Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread
S Bettuzzi, P Davalli, S Davoli, O Chayka, F Rizzi, L Belloni, D Pellacani, G Fregni, S Astancolle, M Fassan, A Corti, R Baffa and A Sala
Oncogene advance online publication, September 28, 2009; doi:10.1038/onc.2009.286
Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma
B Keenen, H Qi, S V Saladi, M Yeung and I L de la Serna
Oncogene advance online publication, September 28, 2009; doi:10.1038/onc.2009.304
PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression
Y Lee, S J Kim, H D Park, E H Park, S M Huang, S B Jeon, J-M Kim, D-S Lim and S S Koh
Oncogene advance online publication, September 28, 2009; doi:10.1038/onc.2009.298
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
G Liu, A Bollig-Fischer, B Kreike, M J van de Vijver, J Abrams, S P Ethier and Z -Q Yang
Oncogene advance online publication, September 28, 2009; doi:10.1038/onc.2009.297
The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts
A Shaw, J Gipp and W Bushman
Oncogene advance online publication, September 28, 2009; doi:10.1038/onc.2009.294
Downregulation of E-cadherin is an essential event in activating -catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells
Q Wang, Z -X Sun, H Allgayer and H -S Yang
Oncogene advance online publication, September 28, 2009; doi:10.1038/onc.2009.302
Short Communication
Chemotherapy induces NEDP1-mediated destabilization of MDM2
I R Watson, B K Li, O Roche, A Blanch, M Ohh and M S Irwin
Oncogene advance online publication, September 28, 2009; doi:10.1038/onc.2009.314
September 21 2009
Review
Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer
J Mullenders and R Bernards
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.295
Original Articles
Lysine 269 is essential for cyclin D1 ubiquitylation by the SCFFbx4/B-crystallin ligase and subsequent proteasome-dependent degradation
O Barbash, E Egan, L L Pontano, J Kosak and J A Diehl
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.287
Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells
S Hassan, M H U Biswas, C Zhang, C Du and K C Balaji
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.291
Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration
X Li, Y Shen, H Ichikawa, T Antes and G S Goldberg
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.278
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
V Mamidipudi and C A Cartwright
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.293
'Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma'
J L Orgaz, O Ladhani, K S Hoek, A Fernández-Barral, D Mihic, O Aguilera, E A Seftor, A Bernad, J L Rodríguez-Peralto, M J C Hendrix, O V Volpert and B Jiménez
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.284
YKL-40, a secreted glycoprotein, promotes tumor angiogenesis
R Shao, K Hamel, L Petersen, Q J Cao, R B Arenas, C Bigelow, B Bentley and W Yan
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.292
Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells
M Shimabe, S Goyama, N Watanabe-Okochi, A Yoshimi, M Ichikawa, Y Imai and M Kurokawa
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.288
Short Communication
Transcription activity is required for p53-dependent tumor suppression
O Gaidarenko and Y Xu
Oncogene advance online publication, September 21, 2009; doi:10.1038/onc.2009.290
September 14 2009
Original Articles
Pro-proliferative FoxM1 is a target of p53-mediated repression
A M Barsotti and C Prives
Oncogene advance online publication, September 14, 2009; doi:10.1038/onc.2009.282
Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire
I H Chan and M L Privalsky
Oncogene advance online publication, September 14, 2009; doi:10.1038/onc.2009.265
PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis
J J Gu, Z Wang, R Reeves and N S Magnuson
Oncogene advance online publication, September 14, 2009; doi:10.1038/onc.2009.276
A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer
R Najdi, A Syed, L Arce, H Theisen, J-HT Ting, F Atcha, A V Nguyen, M Martinez, R F Holcombe, R A Edwards, J L Marsh and M L Waterman
Oncogene advance online publication, September 14, 2009; doi:10.1038/onc.2009.271
Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines
K A Olaussen, F Commo, M Tailler, L Lacroix, I Vitale, S Q Raza, C Richon, P Dessen, V Lazar, J -C Soria and G Kroemer
Oncogene advance online publication, September 14, 2009; doi:10.1038/onc.2009.277
Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions
D Walerych, M B Olszewski, M Gutkowska, A Helwak, M Zylicz and A Zylicz
Oncogene advance online publication, September 14, 2009; doi:10.1038/onc.2009.281
Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner
E di Martino, C G L'Hôte, W Kennedy, D C Tomlinson and M A Knowles
Oncogene advance online publication, September 14, 2009; doi:10.1038/onc.2009.280
Short Communication
Pannexin2 as a novel growth regulator in C6 glioma cells
C P K Lai, J F Bechberger and C C Naus
Oncogene advance online publication, September 14, 2009; doi:10.1038/onc.2009.283
September 7 2009
Original Articles
A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis FREE
J S Blackburn, I Liu, C I Coon and C E Brinckerhoff
Oncogene advance online publication, September 7, 2009; doi:10.1038/onc.2009.272
Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation
F V Jacinto, E Ballestar and M Esteller
Oncogene advance online publication, September 7, 2009; doi:10.1038/onc.2009.267
Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene
M Jaskelioff, W Song, J Xia, C Liu, J Kramer, S Koido, S J Gendler, S K Calderwood and J Gong
Oncogene advance online publication, September 7, 2009; doi:10.1038/onc.2009.268
RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells
Y Jian, Z Gao, J Sun, Q Shen, F Feng, Y Jing and C Yang
Oncogene advance online publication, September 7, 2009; doi:10.1038/onc.2009.275
LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer
D C T Ong, Y M Ho, C Rudduck, K Chin, W -L Kuo, D K H Lie, C L M Chua, P H Tan, K W Eu, F Seow-Choen, C Y Wong, G S Hong, J W Gray and A S G Lee
Oncogene advance online publication, September 7, 2009; doi:10.1038/onc.2009.266
