ADVANCE ONLINE PUBLICATION

The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
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May 22 2017

Review

Integration of hypoxic HIF-α signaling in blood cancers

L Schito, S Rey and M Konopleva

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.119

Original Articles

A novel interaction of PAK4 with PPARγ to regulate Nox1 and radiation-induced epithelial-to-mesenchymal transition in glioma

D Kesanakurti, D Maddirela, Y K Banasavadi-Siddegowda, T-H Lai, Z Qamri, N K Jacob, D Sampath, S Mohanam, B Kaur and V K Puduvalli

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2016.261

STAT3 activation in endothelial cells is important for tumor metastasis via increased cell adhesion molecule expression

K-J Kim, S-H Kwon, J-H Yun, H-S Jeong, H-R Kim, E H Lee, S-K Ye and C-H Cho

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.148

Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway

T-F Kuo, T-Y Chen, S-T Jiang, K-W Chen, Y-M Chiang, Y-J Hsu, Y-J Liu, H-M Chen, K K Yokoyama, K-C Tsai, H-H Yeh, Y-R Chen, M-T Yang, C-Y Yang and W-C Yang

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.156

LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis

J-Y Lee, J-H Park, H-J Choi, H-Y Won, H-s Joo, D-H Shin, M K Park, B Han, K P Kim, T J Lee, C M Croce and G Kong

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.158

A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling

W Li, M Hu, C Wang, H Lu, F Chen, J Xu, Y Shang, F Wang, J Qin, Q Yan, B J Krueger, R Renne, S-J Gao and C Lu

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.139

Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells

C Lin, Y Wang, Y Wang, S Zhang, L Yu, C Guo and H Xu

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.133

Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis

G Semenova, D S Stepanova, C Dubyk, E Handorf, S M Deyev, A J Lazar and J Chernoff

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.143

Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms

C Unger, N Kramer, D Unterleuthner, M Scherzer, A Burian, A Rudisch, M Stadler, M Schlederer, D Lenhardt, A Riedl, S Walter, A Wernitznig, L Kenner, M Hengstschläger, J Schüler, W Sommergruber and H Dolznig

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.116

CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells

Q Wang, J Ma, Y Lu, S Zhang, J Huang, J Chen, J-X Bei, K Yang, G Wu, K Huang, J Chen and S Xu

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.161

UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor

G Xie, X Liu, Y Zhang, W Li, S Liu, Z Chen, B Xu, J Yang, L He, Z Zhang, T Jin, X Yi, L Sun, Y Shang and J Liang

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.157

Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp

Y Zhang, Y Hu, J-L Wang, H Yao, H Wang, L Liang, C Li, H Shi, Y Chen, J-Y Fang and J Xu

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.152

CECR1-mediated cross talk between macrophages and vascular mural cells promotes neovascularization in malignant glioma Open

C Zhu, I Chrifi, D Mustafa, M van der Weiden, P J M Leenen, D J Duncker, J M Kros and C Cheng

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.145

Short Communication

Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth

X Li, Y Kang, D Roife, Y Lee, M Pratt, M R Perez, B Dai, E J Koay and J B Fleming

Oncogene advance online publication, May 22, 2017; doi:10.1038/onc.2017.125

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May 15 2017

Review

A tumor suppressor role for C/EBPα in solid tumors: more than fat and blood

A R Lourenço and P J Coffer

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.151

Original Articles

Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover

H-C Chi, S-L Chen, S-L Lin, C-Y Tsai, W-Y Chuang, Y-H Lin, Y-H Huang, M-M Tsai, C-T Yeh and K-H Lin

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.136

A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer

E-J Choi, B-J Jung, S-H Lee, H-S Yoo, E-A Shin, H-J Ko, S Chang, S-Y Kim and S-M Jeon

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.153

Fibulin-3 promotes muscle-invasive bladder cancer

A L Han, B A Veeneman, L El-Sawy, K C Day, M L Day, S A Tomlins and E T Keller

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.149

Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development Open

B Han, H K Park, T Ching, J Panneerselvam, H Wang, Y Shen, J Zhang, L Li, R Che, L Garmire and P Fei

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.150

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells Open

D Kawauchi, R J Ogg, L Liu, D J H Shih, D Finkelstein, B L Murphy, J E Rehg, A Korshunov, C Calabrese, F Zindy, T Phoenix, Y Kawaguchi, J Gronych, R J Gilbertson, P Lichter, A Gajjar, M Kool, P A Northcott, S M Pfister and M F Roussel

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.110

VEGFA links self-renewal and metastasis by inducing Sox2 to repress miR-452, driving Slug Open

M Kim, K Jang, P Miller, M Picon-Ruiz, T M Yeasky, D El-Ashry and J M Slingerland

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.4

Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells

H Marzook, S Deivendran, B George, G Reshmi, T R Santhoshkumar, R Kumar and M R Pillai

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.19

Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer

M L Read, J C Fong, B Modasia, A Fletcher, W Imruetaicharoenchoke, R J Thompson, H Nieto, J J Reynolds, A Bacon, U Mallick, A Hackshaw, J C Watkinson, K Boelaert, A S Turnell, V E Smith and C J McCabe

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.154

Tumour exosomes from cells harbouring PTPRZ1–MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma Open

A-L Zeng, W Yan, Y-W Liu, Z Wang, Q Hu, E Nie, X Zhou, R Li, X-F Wang, T Jiang and Y-P You

Oncogene advance online publication, May 15, 2017; doi:10.1038/onc.2017.134

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May 8 2017

Original Articles

CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis Open

X W Chen, T J Yu, J Zhang, Y Li, H L Chen, G F Yang, W Yu, Y Z Liu, X X Liu, C F Duan, H L Tang, M Qiu, C L Wang, H Zheng, J Yue, A M Guo and J Yang

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.118

Restoring PU.1 induces apoptosis and modulates viral transactivation via interferon-stimulated genes in primary effusion lymphoma

H Goto, R Kariya, E Kudo, Y Okuno, K Ueda, H Katano and S Okada

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.138

Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization

H Guo, Q Zhu, X Yu, S B Merugu, H B Mangukiya, N Smith, Z Li, B Zhang, H Negi, R Rong, K Cheng, Z Wu and D Li

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.132

Oncogenic activity of amplified miniature chromosome maintenance 8 in human malignancies

D-M He, B-G Ren, S Liu, L-Z Tan, K Cieply, G Tseng, Y P Yu and J-H Luo

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.123

Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4

X Hu, S-H Dong, J Chen, X Z Zhou, R Chen, S Nair, K P Lu and L-F Chen

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.137

The RB–IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity

S Kitajima, A Yoshida, S Kohno, F Li, S Suzuki, N Nagatani, Y Nishimoto, N Sasaki, H Muranaka, Y Wan, T C Thai, N Okahashi, F Matsuda, H Shimizu, T Nishiuchi, Y Suzuki, K Tominaga, N Gotoh, M Suzuki, M E Ewen, D A Barbie, O Hirose, T Tanaka and C Takahashi

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.124

The AP-1 transcription factor FOSL1 causes melanocyte reprogramming and transformation

K Maurus, A Hufnagel, F Geiger, S Graf, C Berking, A Heinemann, A Paschen, S Kneitz, C Stigloher, E Geissinger, C Otto, A Bosserhoff, M Schartl and S Meierjohann

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.135

Thrombospondin-4 mediates TGF-β-induced angiogenesis

S Muppala, R Xiao, I Krukovets, D Verbovetsky, R Yendamuri, N Habib, P Raman, E Plow and O Stenina-Adognravi

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.140

Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination

J H Wald, J Hatakeyama, I Printsev, A Cuevas, W H D Fry, M J Saldana, K VanderVorst, A Rowson-Hodel, J M Angelastro, C Sweeney and K L Carraway 3rd

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.126

Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer

A C West, K Tang, H Tye, L Yu, N Deng, M Najdovska, S J Lin, J J Balic, E Okochi-Takada, P McGuirk, B Keogh, W McCormack, P S Bhathal, M Reilly, M Oshima, T Ushijima, P Tan and B J Jenkins

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.121

A positive crosstalk between CXCR4 and CXCR2 promotes gastric cancer metastasis

Z Xiang, Z-J Zhou, G-K Xia, X-H Zhang, Z-W Wei, J-T Zhu, J Yu, W Chen, Y He, R E Schwarz, R A Brekken, N Awasthi and C-H Zhang

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.108

Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways Open

B Xin, M Yamamoto, K Fujii, T Ooshio, X Chen, Y Okada, K Watanabe, N Miyokawa, H Furukawa and Y Nishikawa

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.114

The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression

F Zhang, H Tang, Y Jiang and Z Mao

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.127

Short Communication

Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53

Z Li and Y Xiong

Oncogene advance online publication, May 8, 2017; doi:10.1038/onc.2017.141

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May 1 2017

Original Articles

Genome-wide DNA methylation profiling reveals cancer-associated changes within early colonic neoplasia

M P Hanley, M A Hahn, A X Li, X Wu, J Lin, J Wang, A H Choi, Z Ouyang, Y Fong, G P Pfeifer, T J Devers and D W Rosenberg

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.130

MiR-181b modulates EGFR-dependent VCAM-1 expression and monocyte adhesion in glioblastoma

Y-S Liu, H-Y Lin, S-W Lai, C-Y Huang, B-R Huang, P-Y Chen, K-C Wei and D-Y Lu

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.129

Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer

M Pek, S M J M Yatim, Y Chen, J Li, M Gong, X Jiang, F Zhang, J Zheng, X Wu and Q Yu

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.120

Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells

E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata and K Miyazono

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.112

Insulin resistance in vascular endothelial cells promotes intestinal tumour formation

X Wang, M-F Häring, T Rathjen, S M Lockhart, D Sørensen, S Ussar, L M Rasmussen, M M Bertagnolli, C R Kahn and C Rask-Madsen

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.107

INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma

N Yang, E L-H Leung, C Liu, L Li, T Eguether, X-J Jun Yao, E C Jones, D A Norris, A Liu, R A Clark, D R Roop, G J Pazour, K R Shroyer and J Chen

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.117

MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells

J Zhao, Y Wang, C Mu, Y Xu and J Sang

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.131

Short Communications

Ribonucleotide reductase represents a novel therapeutic target in primary effusion lymphoma

L Dai, Z Lin, J Qiao, Y Chen, E K Flemington and Z Qin

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.122

MYCN induces neuroblastoma in primary neural crest cells Open

R R Olsen, J H Otero, J García-López, K Wallace, D Finkelstein, J E Rehg, Z Yin, Y-D Wang and K W Freeman

Oncogene advance online publication, May 1, 2017; doi:10.1038/onc.2017.128

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April 24 2017

Review

Playing polo during mitosis: PLK1 takes the lead

G Combes, I Alharbi, L G Braga and S Elowe

Oncogene advance online publication, April 24, 2017; doi:10.1038/onc.2017.113

Original Articles

Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins

A Antignani, D Segal, N Simon, R J Kreitman, D Huang and D J FitzGerald

Oncogene advance online publication, April 24, 2017; doi:10.1038/onc.2017.111

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

Y-L Hsu, J-Y Hung, W-A Chang, Y-S Lin, Y-C Pan, P-H Tsai, C-Y Wu and P-L Kuo

Oncogene advance online publication, April 24, 2017; doi:10.1038/onc.2017.105

Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress

J Li, Q Huang, X Long, X Guo, X Sun, X Jin, Z Li, T Ren, P Yuan, X Huang, H Zhang and J Xing

Oncogene advance online publication, April 24, 2017; doi:10.1038/onc.2017.98

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells Open

N Niu, I Mercado-Uribe and J Liu

Oncogene advance online publication, April 24, 2017; doi:10.1038/onc.2017.72

p14ARF interacts with the focal adhesion kinase and protects cells from anoikis Open

M Vivo, R Fontana, M Ranieri, G Capasso, T Angrisano, A Pollice, V Calabrò and G La Mantia

Oncogene advance online publication, April 24, 2017; doi:10.1038/onc.2017.104

Short Communication

MRE11 stability is regulated by CK2-dependent interaction with R2TP complex Open

P von Morgen, K Burdova, T G Flower, N J O'Reilly, S J Boulton, S J Smerdon, L Macurek and Z Hořejší

Oncogene advance online publication, April 24, 2017; doi:10.1038/onc.2017.99

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April 17 2017

Original Article

Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours

H Yurugi, F Marini, C Weber, K David, Q Zhao, H Binder, L Désaubry and K Rajalingam

Oncogene advance online publication, April 17, 2017; doi:10.1038/onc.2017.93

Original Articles

SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein

C Geng, S Kaochar, M Li, K Rajapakshe, W Fiskus, J Dong, C Foley, B Dong, L Zhang, O-J Kwon, S S Shah, M Bolaki, L Xin, M Ittmann, B W O'Malley, C Coarfa and N Mitsiades

Oncogene advance online publication, April 17, 2017; doi:10.1038/onc.2017.80

Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition

E Hendrick, P Peixoto, A Blomme, C Polese, N Matheus, J Cimino, A Frère, A Mouithys-Mickalad, D Serteyn, L Bettendorff, B Elmoualij, P De Tullio, G Eppe, F Dequiedt, V Castronovo and D Mottet

Oncogene advance online publication, April 17, 2017; doi:10.1038/onc.2017.103

Complex regulation of LCoR signaling in breast cancer cells Open

S Jalaguier, C Teyssier, T Nait Achour, A Lucas, S Bonnet, C Rodriguez, N Elarouci, M Lapierre and V Cavaillès

Oncogene advance online publication, April 17, 2017; doi:10.1038/onc.2017.97

Tumor-derived fibulin-3 activates pro-invasive NF-κB signaling in glioblastoma cells and their microenvironment

M S Nandhu, A Kwiatkowska, V Bhaskaran, J Hayes, B Hu and M S Viapiano

Oncogene advance online publication, April 17, 2017; doi:10.1038/onc.2017.109

Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance

K A Whelan, P M Chandramouleeswaran, K Tanaka, M Natsuizaka, M Guha, S Srinivasan, D S Darling, Y Kita, S Natsugoe, J D Winkler, A J Klein-Szanto, R K Amaravadi, N G Avadhani, A K Rustgi and H Nakagawa

Oncogene advance online publication, April 17, 2017; doi:10.1038/onc.2017.102

Short Communication

Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia

E T Sumner, A T Chawla, A D Cororaton, J E Koblinski, R C Kovi, I M Love, B B Szomju, S Korwar, K C Ellis and S R Grossman

Oncogene advance online publication, April 17, 2017; doi:10.1038/onc.2017.106

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April 10 2017

Review

New factors in mammalian DNA repair—the chromatin connection Open

G Raschellà, G Melino and M Malewicz

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.60

Original Articles

Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b Open

Y Chen, C Zeng, Y Zhan, H Wang, X Jiang and W Li

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.100

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma

V Colicchia, M Petroni, G Guarguaglini, F Sardina, M Sahún-Roncero, M Carbonari, B Ricci, C Heil, C Capalbo, F Belardinilli, A Coppa, G Peruzzi, I Screpanti, P Lavia, A Gulino and G Giannini

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.40

NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma

P-S Hu, Q-S Xia, F Wu, D-k Li, Y-j Qi, Y Hu, Z-Z Wei, S-S Li, N-Y Tian, Q-F Wei, L-J Shen, B Yin, T Jiang, J-G Yuan, B-Q Qiang, W Han and X-Z Peng

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.34

Regulation of spindle integrity and mitotic fidelity by BCCIP Open

S C Huhn, J Liu, C Ye, H Lu, X Jiang, X Feng, S Ganesan, E White and Z Shen

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.92

Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA Open

W Lu, F Cheng, W Yan, X Li, X Yao, W Song, M Liu, X Shen, H Jiang, J Chen, J Li and J Huang

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.41

Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells

A Motzik, E Amir, T Erlich, J Wang, B-G Kim, J M Han, J H Kim, H Nechushtan, M Guo, E Razin and S Tshori

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.81

PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311

J Yang, K Liu, J Yang, B Jin, H Chen, X Zhan, Z Li, L Wang, X Shen, M Li, W Yu and Z Mao

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.96

CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer Open

E Zoni, L Chen, S Karkampouna, Z Granchi, E I Verhoef, F La Manna, J Kelber, R C M Pelger, M D Henry, E Snaar-Jagalska, G J L H van Leenders, L Beimers, P Kloen, P C Gray, G van der Pluijm and M Kruithof-de Julio

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.87

Corrigendum

Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment FREE

B Joseph, P Marchetti, P Formstecher, G Kroemer, R Lewensohn and B Zhivotovsky

Oncogene advance online publication, April 10, 2017; doi:10.1038/onc.2017.78

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April 3 2017

Review

Estrogen receptors in breast and bone: from virtue of remodeling to vileness of metastasis

I Bado, Z Gugala, S A W Fuqua and X H-F Zhang

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.94

Original Articles

P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model

M Batisse-Lignier, I Sahut-Barnola, F Tissier, T Dumontet, M Mathieu, C Drelon, J-C Pointud, C Damon-Soubeyrand, G Marceau, J-L Kemeny, J Bertherat, I Tauveron, P Val, A Martinez and A-M Lefrançois-Martinez

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.54

circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family Open

L Chen, S Zhang, J Wu, J Cui, L Zhong, L Zeng and S Ge

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.89

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1 Open

N Cohen, O Shani, Y Raz, Y Sharon, D Hoffman, L Abramovitz and N Erez

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.65

JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21 Open

B Colleoni, S Paternot, J M Pita, X Bisteau, K Coulonval, R J Davis, E Raspé and P P Roger

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.7

Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis

S Deguchi, K Katsushima, A Hatanaka, K Shinjo, F Ohka, T Wakabayashi, H Zong, A Natsume and Y Kondo

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.88

ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82 Open

V Di Giacomo, T V Tian, A Mas, M Pecoraro, L Batlle-Morera, L Noya, J Martín-Caballero, J Ruberte and W M Keyes

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.42

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells Open

T H Dovmark, M Saccomano, A Hulikova, F Alves and P Swietach

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.71

Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP1–17

J S Frieling, G Shay, V Izumi, S T Aherne, R G Saul, M Budzevich, J Koomen and C C Lynch

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.70

Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype

X Guo, J L Koff, A B Moffitt, M Cinar, S Ramachandiran, Z Chen, J M Switchenko, M Mosunjac, S G Neill, K P Mann, M Bagirov, Y Du, Y Natkunam, H J Khoury, M R Rossi, W Harris, C R Flowers, I S Lossos, L H Boise, S S Dave, J Kowalski and L Bernal-Mizrachi

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.90

Angiomotin-like 2 interacts with and negatively regulates AKT

H Han, B Yang and W Wang

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.101

Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours

G Itoh, S Chida, K Yanagihara, M Yashiro, N Aiba and M Tanaka

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.49

Abl kinase regulation by BRAF/ERK and cooperation with Akt in melanoma

A Jain, R Tripathi, C P Turpin, C Wang and R Plattner

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.76

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis Open

T C Kenny, P Hart, M Ragazzi, M Sersinghe, J Chipuk, M A K Sagar, K W Eliceiri, T LaFramboise, S Grandhi, J Santos, A K Riar, L Papa, M D'Aurello, G Manfredi, M G Bonini and D Germain

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.52

Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis

C-J Ko, S-W Lan, Y-C Lu, T-S Cheng, P-F Lai, C-H Tsai, T-W Hsu, H-Y Lin, H-Y Shyu, S-R Wu, H-H Lin, P-W Hsiao, C-H Chen, H-P Huang and M-S Lee

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.82

Interferon γ is a STAT1-dependent direct inducer of BCL6 expression in imatinib-treated chronic myeloid leukemia cells

H S Madapura, N Nagy, D Ujvari, T Kallas, M C L Kröhnke, S Amu, M Björkholm, L Stenke, P K Mandal, J S McMurray, M Keszei, L S Westerberg, H Cheng, F Xue, G Klein, E Klein and D Salamon

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.85

Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells

T M Mertz, A G Baranovskiy, J Wang, T H Tahirov and P V Shcherbakova

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.22

Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition

T K Moyo, C S Wilson, D J Moore and C M Eischen

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.95

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ FREE

A Noto, C De Vitis, M E Pisanu, G Roscilli, G Ricci, A Catizone, G Sorrentino, G Chianese, O Taglialatela-Scafati, D Trisciuoglio, D Del Bufalo, M Di Martile, A Di Napoli, L Ruco, S Costantini, Z Jakopin, A Budillon, G Melino, G Del Sal, G Ciliberto and R Mancini

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.75

Co-dependency of PKCδ and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer

A M Ohm, A-C Tan, L E Heasley and M E Reyland

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.27

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma Open

A Po, M Silvano, E Miele, C Capalbo, A Eramo, V Salvati, M Todaro, Z M Besharat, G Catanzaro, D Cucchi, S Coni, L Di Marcotullio, G Canettieri, A Vacca, G Stassi, E De Smaele, M Tartaglia, I Screpanti, R De Maria and E Ferretti

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.91

TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function Open

D R Principe, A M Diaz, C Torres, R J Mangan, B DeCant, R McKinney, M-S Tsao, A Lowy, H G Munshi, B Jung and P J Grippo

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2016.500

Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression

Q Qi, S S Kang, S Zhang, C Pham, H Fu, D J Brat and K Ye

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.67

Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer

R Shakya, G A Tarulli, L Sheng, N A Lokman, C Ricciardelli, K I Pishas, C I Selinger, M R J Kohonen-Corish, W A Cooper, A G Turner, P M Neilsen and D F Callen

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.66

DNA-binding mechanism of the Hippo pathway transcription factor TEAD4

Z Shi, F He, M Chen, L Hua, W Wang, S Jiao and Z Zhou

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.24

HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss

C H Shin, J P Robinson, J A Sonnen, A E Welker, D X Yu, M W VanBrocklin and S L Holmen

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.83

Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients Open

H Tsoi, K C Lam, Y Dong, X Zhang, C K Lee, J Zhang, S Chien Ng, S S Man Ng, S Zheng, Y Chen, J Fang and J Yu

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.86

PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4

N Ueno, N Nishimura, S Ueno, S Endo, H Tatetsu, S Hirata, H Hata, M Matsuoka, H Mitsuya and Y Okuno

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.79

Transcription factor SPZ1 promotes TWIST-mediated epithelial–mesenchymal transition and oncogenesis in human liver cancer Open

L-T Wang, S-S Chiou, C-Y Chai, E Hsi, C-M Chiang, S-K Huang, S-N Wang, K K Yokoyama and S-H Hsu

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.69

Short Communications

Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo

V Cesarini, E Guida, F Todaro, S Di Agostino, V Tassinari, S Nicolis, R Favaro, S Caporali, P M Lacal, E Botti, A Costanzo, P Rossi, E A Jannini and S Dolci

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.53

Sox2 is dispensable for primary melanoma and metastasis formation

S M Schaefer, C Segalada, P F Cheng, M Bonalli, V Parfejevs, M P Levesque, R Dummer, S K Nicolis and L Sommer

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.55

Corrigenda

Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer Open

J Jen, L-L Lin, F-Y Lo, H-T Chen, S-Y Liao, Y-A Tang, W-C Su, R Salgia, C-L Hsu, H-C Huang, H-F Juan and Y-C Wang

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.77

Activation of CK1ε by PP2A/PR61ε is required for the initiation of Wnt signaling FREE

M Vinyoles, B Del Valle-Pérez, J Curto, M Padilla, A Villarroel, J Yang, A G de Herreros and M Duñach

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2017.84

Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia FREE

W Zhai, Y Sun, M Jiang, M Wang, T A Gasiewicz, J Zheng and C Chang

Oncogene advance online publication, April 3, 2017; doi:10.1038/onc.2016.514

Top

March 27 2017

Original Articles

Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice Open

H Chen, W Cai, E S H Chu, J Tang, C-C Wong, S H Wong, W Sun, Q Liang, J Fang, Z Sun and J Yu

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.73

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Open

N L E Harris, C Vennin, J R W Conway, K L Vine, M Pinese, M J Cowley, R F Shearer, M C Lucas, D Herrmann, A H Allam, M Pajic, J P Morton, Australian Pancreatic Cancer Genome Initiative, A V Biankin, M Ranson, P Timpson and D N Saunders

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.63

MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles

W He, C Wang, R Mu, P Liang, Z Huang, J Zhang and L Dong

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.62

IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth

C Jungnickel, L H Schmidt, L Bittigkoffer, L Wolf, A Wolf, F Ritzmann, A Kamyschnikow, C Herr, M D Menger, T Spieker, R Wiewrodt, R Bals and C Beisswenger

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.28

The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells Open

L Mi, F Zhu, X Yang, J Lu, Y Zheng, Q Zhao, X Wen, A Lu, M Wang, M Zheng, J Ji and J Sun

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.74

MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation

K Otsubo, H Goto, M Nishio, K Kawamura, S Yanagi, W Nishie, T Sasaki, T Maehama, H Nishina, K Mimori, T Nakano, H Shimizu, T W Mak, K Nakao, Y Nakanishi and A Suzuki

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.58

Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist

D Ruan, J He, C-F Li, H-J Lee, J Liu, H-K Lin and C-H Chan

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.64

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

Y Shang, J He, Y Wang, Q Feng, Y Zhang, J Guo, J Li, S Li, Y Wang, G Yan, F Ren, Y Shi, J Xu, N Zeps, Y Zhai, D He and Z Chang

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.31

Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells Open

H Takahashi, J Inoue, K Sakaguchi, M Takagi, S Mizutani and J Inazawa

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.59

MRL proteins cooperate with activated Ras in glia to drive distinct oncogenic outcomes Open

E Taylor, N Alqadri, L Dodgson, D Mason, E Lyulcheva, G Messina and D Bennett

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.68

Deletion of endothelial cell-specific liver kinase B1 increases angiogenesis and tumor growth via vascular endothelial growth factor

W Zhang, Y Ding, C Zhang, Q Lu, Z Liu, K Coughlan, I Okon and M-H Zou

Oncogene advance online publication, March 27, 2017; doi:10.1038/onc.2017.61

Top

March 20 2017

Original Articles

Iron addiction: a novel therapeutic target in ovarian cancer

D Basuli, L Tesfay, Z Deng, B Paul, Y Yamamoto, G Ning, W Xian, F McKeon, M Lynch, C P Crum, P Hegde, M Brewer, X Wang, L D Miller, N Dyment, F M Torti and S V Torti

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.11

OCT4 controls mitotic stability and inactivates the RB tumor suppressor pathway to enhance ovarian cancer aggressiveness

E Comisso, M Scarola, M Rosso, S Piazza, S Marzinotto, Y Ciani, M Orsaria, L Mariuzzi, C Schneider, S Schoeftner and R Benetti

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.20

The drebrin/EB3 pathway drives invasive activity in prostate cancer Open

A E Dart, D C Worth, G Muir, A Chandra, J D Morris, C McKee, C Verrill, R J Bryant and P R Gordon-Weeks

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.45

Compromised BRCA1–PALB2 interaction is associated with breast cancer risk

T K Foo, M Tischkowitz, S Simhadri, T Boshari, N Zayed, K A Burke, S H Berman, P Blecua, N Riaz, Y Huo, Y C Ding, S L Neuhausen, B Weigelt, J S Reis-Filho, W D Foulkes and B Xia

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.46

CCDC178 promotes hepatocellular carcinoma metastasis through modulation of anoikis

X Hu, Y Zhao, L Wei, B Zhu, D Song, J Wang, L Yu and J Wu

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.10

FOXA1 inhibits prostate cancer neuroendocrine differentiation

J Kim, H Jin, J C Zhao, Y A Yang, Y Li, X Yang, X Dong and J Yu

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.50

CAMK2γ in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation

X Ma, Z Meng, L Jin, Z Xiao, X Wang, W M Tsark, L Ding, Y Gu, J Zhang, B Kim, M He, X Gan, J E Shively, H Yu, R Xu and W Huang

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.16

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic Open

A D Marshall, C G Bailey, K Champ, M Vellozzi, P O'Young, C Metierre, Y Feng, A Thoeng, A M Richards, U Schmitz, M Biro, R Jayasinghe, L Ding, L Anderson, E R Mardis and J E J Rasko

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.25

The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis

M Sechler, J K Parrish, D K Birks and P Jedlicka

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.44

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

V Thewes, R Simon, M Hlevnjak, M Schlotter, P Schroeter, K Schmidt, Y Wu, T Anzeneder, W Wang, P Windisch, M Kirchgäßner, N Melling, N Kneisel, R Büttner, U Deuschle, H P Sinn, A Schneeweiss, S Heck, S Kaulfuss, H Hess-Stumpp, J G Okun, G Sauter, A E Lykkesfeldt, M Zapatka, B Radlwimmer, P Lichter and M Tönjes

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.32

XRN2 promotes EMT and metastasis through regulating maturation of miR-10a

H Zhang, Y Lu, E Chen, X Li, B Lv, H G Vikis and P Liu

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.39

Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis Open

Y Zhang, Y-J Ren, L-C Guo, C Ji, J Hu, H-H Zhang, Q-H Xu, W-D Zhu, Z-J Ming, Y-S Yuan, X Ren, J Song and J-M Yang

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.51

The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP–PKA–EGFR–STAT3 axis

M Zhou, M T S Mok, H Sun, A W Chan, Y Huang, A S L Cheng and G Xu

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.38

Corrigendum

Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association FREE

Y-C Yang, T-Y Cheng, S-M Huang, C-Y Su, P-W Yang, J-M Lee, C-K Chen, M Hsiao, K-T Hua and M-L Kuo

Oncogene advance online publication, March 20, 2017; doi:10.1038/onc.2017.18

Top

March 13 2017

Reviews

Census and evaluation of p53 target genes Open

M Fischer

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2016.502

FOXC1: an emerging marker and therapeutic target for cancer

B Han, N Bhowmick, Y Qu, S Chung, A E Giuliano and X Cui

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.48

Original Articles

MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small-cell lung cancer

A Bouillez, H Rajabi, C Jin, M Samur, A Tagde, M Alam, M Hiraki, T Maeda, X Hu, D Adeegbe, S Kharbanda, K-K Wong and D Kufe

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.47

MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway

L Deng, J Tang, H Yang, C Cheng, S Lu, R Jiang and B Sun

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2016.491

Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression Open

R Gupta, Q Yang, S K Dogra and N Wajapeyee

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.37

Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling Open

D J Junk, B L Bryson, J M Smigiel, N Parameswaran, C A Bartel and M W Jackson

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.33

MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF Open

B Li, W W Xu, L Han, K T Chan, S W Tsao, N P Y Lee, S Law, L Y Xu, E M Li, K W Chan, Y R Qin, X Y Guan, Q Y He and A L M Cheung

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.29

Targeting Lyn regulates Snail family shuttling and inhibits metastasis

D Thaper, S Vahid, K M Nip, I Moskalev, X Shan, S Frees, M E Roberts, K Ketola, K W Harder, C Gregory-Evans, J L Bishop and A Zoubeidi

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.5

Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome Open

G V Walls, M Stevenson, K E Lines, P J Newey, A A C Reed, M R Bowl, J Jeyabalan, B Harding, K J Bradley, S Manek, J Chen, P Wang, B O Williams, B T Teh and R V Thakker

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.43

Short Communication

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

S Hernández-Pérez, E Cabrera, E Salido, M Lim, L Reid, S R Lakhani, K K Khanna, J M Saunus and R Freire

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.21

Corrigenda

DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia Open

H J Ferreira, H Heyn, M Vizoso, C Moutinho, E Vidal, A Gomez, A Martínez-Cardús, L Simó-Riudalbas, S Moran, E Jost and M Esteller

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.57

Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect FREE

Y Xu, S Miriyala, F Fang, V Bakthavatchalu, T Noel, D M Schnell, C Wang, W H St Clair and D K St Clair

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2016.513

Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial–mesenchymal transition Open

Q Zhang, T Wei, K Shim, K Wright, K Xu, H L Palka-Hamblin, A Jurkevich and S Khare

Oncogene advance online publication, March 13, 2017; doi:10.1038/onc.2017.56

Top

March 6 2017

Original Articles

Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer

E A Hanse, C Ruan, M Kachman, D Wang, X H Lowman and A Kelekar

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.36

EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis

D M Hardbower, L A Coburn, M Asim, K Singh, J C Sierra, D P Barry, A P Gobert, M B Piazuelo, M K Washington and K T Wilson

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.23

GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness Open

M-C Lin, J-J Lin, C-L Hsu, H-F Juan, P-J Lou and M-C Huang

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.8

The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma Open

T Tao, S B Sondalle, H Shi, S Zhu, A R Perez-Atayde, J Peng, S J Baserga and A T Look

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2016.527

Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α

W Wan, K Peng, M Li, L Qin, Z Tong, J Yan, B Shen and C Yu

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.13

Differing tumor-suppressor functions of Arf and p53 in murine basal cell carcinoma initiation and progression

G Y Wang, C N Wood, J A Dolorito, E Libove and E H Epstein Jr

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.12

Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization Open

Jr-M Yang, P Schiapparelli, H-N Nguyen, A Igarashi, Q Zhang, S Abbadi, L M Amzel, H Sesaki, A Quiñones-Hinojosa and M Iijima

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2016.493

Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma Open

H Yang, D A Kircher, K H Kim, A H Grossmann, M W VanBrocklin, S L Holmen and J P Robinson

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2016.526

SND1 acts as a novel gene transcription activator recognizing the conserved Motif domains of Smad promoters, inducing TGFβ1 response and breast cancer metastasis

L Yu, Y Di, L Xin, Y Ren, X Liu, X Sun, W Zhang, Z Yao and J Yang

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.30

NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma

Z Zhai, W Liu, M Kaur, Y Luo, J Domenico, J M Samson, Y G Shellman, D A Norris, C A Dinarello, R A Spritz and M Fujita

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.26

An FGFR inhibitor converts the tumor promoting effect of TGF-β by the induction of fibroblast-associated genes of hepatoma cells

H-R Zhang, X-D Wang, X Yang, D Chen, J Hao, R Cao and X-Z Wu

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2016.512

Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma

W Zhang, R Hong, L Xue, Y Ou, X Liu, Z Zhao, W Xiao, D Dong, L Dong, M Fu, L Ma, N Lu, H Chen, Y Song and Q Zhan

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.15

LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1α translation

C Zhou, C Huang, J Wang, H Huang, J Li, Q Xie, Y Liu, J Zhu, Y Li, D Zhang, Q Zhu and C Huang

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.14

Short Communication

CpG-based immunotherapy impairs antitumor activity of BRAF inhibitors in a B-cell-dependent manner Open

L Huang, Z Wang, C Liu, C Xu, R M Mbofung, J A McKenzie, H Khong, P Hwu and W Peng

Oncogene advance online publication, March 6, 2017; doi:10.1038/onc.2017.35

Top

February 20 2017

Original Articles

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy Open

B A Castro, P Flanigan, A Jahangiri, D Hoffman, W Chen, R Kuang, M De Lay, G Yagnik, J R Wagner, S Mascharak, M Sidorov, S Shrivastav, G Kohanbash, H Okada and M K Aghi

Oncogene advance online publication, February 20, 2017; doi:10.1038/onc.2017.1

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis FREE

L Jin, J Chun, C Pan, G N Alesi, D Li, K R Magliocca, Y Kang, Z G Chen, D M Shin, F R Khuri, J Fan and S Kang

Oncogene advance online publication, February 20, 2017; doi:10.1038/onc.2017.6

The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation

Y Li, T Zhou, Y Wang, C Ning, Z Lv, G Han, J C Morris, E N Taylor, R Wang, H Xiao, C Hou, Y Ma, B Shen, J Feng, R Guo, Y Li and G Chen

Oncogene advance online publication, February 20, 2017; doi:10.1038/onc.2017.2

Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway Open

M-J Wu, M R Kim, Y-S Chen, J-Y Yang and C-J Chang

Oncogene advance online publication, February 20, 2017; doi:10.1038/onc.2016.467

Corrigendum

Girdin maintains the stemness of glioblastoma stem cells FREE

A Natsume, T Kato, S Kinjo, A Enomoto, H Toda, S Shimato, F Ohka, K Motomura, Y Kondo, T Miyata, M Takahashi and T Wakabayashi

Oncogene advance online publication, February 20, 2017; doi:10.1038/onc.2017.17

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February 13 2017

Original Articles

C-Met/miR-130b axis as novel mechanism and biomarker for castration resistance state acquisition

A Cannistraci, G Federici, A Addario, A L Di Pace, L Grassi, G Muto, D Collura, M Signore, L De Salvo, S Sentinelli, G Simone, M Costantini, S Nanni, A Farsetti, V Coppola, R De Maria and D Bonci

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.505

TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas

Z Liu, K Yanagisawa, S Griesing, M Iwai, K Kano, N Hotta, T Kajino, M Suzuki and T Takahashi

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.524

Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors Open

Y Obata, K Horikawa, T Takahashi, Y Akieda, M Tsujimoto, J A Fletcher, H Esumi, T Nishida and R Abe

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.519

A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial–mesenchymal transition in cancer

N V Sankpal, T P Fleming, P K Sharma, H J Wiedner and W E Gillanders

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.504

Loss of KLF4 and consequential downregulation of Smad7 exacerbate oncogenic TGF-β signaling in and promote progression of hepatocellular carcinoma

H Sun, Z Peng, H Tang, D Xie, Z Jia, L Zhong, S Zhao, Z Ma, Y Gao, L Zeng, R Luo and K Xie

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.447

Ras–Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function

T Zahavi, A Maimon, T Kushnir, R Lange, E Berger, D Kornspan, R Grossman, S Anzi, E Shaulian, R Karni, H Nechushtan and Z Paroush

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.517

Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia Open

M H A van Attekum, S Terpstra, E Slinger, M von Lindern, P D Moerland, A Jongejan, A P Kater and E Eldering

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.515

Short Communications

CyclinD-CDK4/6 complexes phosphorylate CDC25A and regulate its stability

C Dozier, L Mazzolini, C Cénac, C Froment, O Burlet-Schiltz, A Besson and S Manenti

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.506

Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms Open

H Y Lau, J Tang, P J Casey and M Wang

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.508

Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation

I D Tonks, P Mukhopadhyay, W A Schroder, A Sorolla, A W Mould, H Y Handoko, B Ferguson, H K Muller, P Keith, N K Hayward, G J Walker and G F Kay

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2016.511

Corrigendum

CFTR is a tumor suppressor gene in murine and human intestinal cancer FREE

B L N Than, J F Linnekamp, T K Starr, D A Largaespada, A Rod, Y Zhang, V Bruner, J Abrahante, A Schumann, T Luczak, J Walter, A Niemczyk, M G O'Sullivan, J P Medema, R J A Fijneman, G A Meijer, E Van den Broek, C A Hodges, P M Scott, L Vermeulen and R T Cormier

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2017.3

Retraction

PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2 FREE

J Shen, H Vakifahmetoglu, H Stridh, B Zhivotovsky and K G Wiman

Oncogene advance online publication, February 13, 2017; doi:10.1038/onc.2017.9

Top

February 6 2017

Letter to the Editor

Pancreatic fibroblast exosomes regulate survival of cancer cells

S Suklabaidya, P Dash and S Senapati

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.528

Original Articles

Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target

C-H Chen, L W R Fong, E Yu, R Wu, J F Trott and R H Weiss

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.510

Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ

M Escoll, R Gargini, A Cuadrado, I M Anton and F Wandosell

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.518

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR Open

T-S Lau, L K-Y Chan, E C-H Wong, C W-C Hui, K Sneddon, T-H Cheung, S-F Yim, J H-S Lee, C S-Y Yeung, T K-H Chung and J Kwong

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.509

Chemerin has a protective role in hepatocellular carcinoma by inhibiting the expression of IL-6 and GM-CSF and MDSC accumulation

Y Lin, X Yang, W Liu, B Li, W Yin, Y Shi and R He

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.516

CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling

C Lin, W Liao, Y Jian, Y Peng, X Zhang, L Ye, Y Cui, B Wang, X Wu, Z Xiong, S Wu, J Li, X Wang and L Song

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.525

Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma

S Luo, Y Li, R Ma, J Liu, P Xu, H Zhang, K Tang, J Ma, N Liu, Y Zhang, Y Sun, T Ji, X Liang, X Yin, Y Liu, W Tong, Y Niu, N Wang, X Wang and B Huang

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.520

KLF6 depletion promotes NF-κB signaling in glioblastoma Open

A P Masilamani, R Ferrarese, E Kling, N K Thudi, H Kim, D M Scholtens, F Dai, M Hadler, T Unterkircher, L Platania, A Weyerbrock, M Prinz, G Y Gillespie, G R Harsh IV, M Bredel and M S Carro

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.507

The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia

J Wakim, E Arman, S Becker-Herman, M P Kramer, E Bakos, I Shachar and A Elson

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.523

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor Open

G Weitsman, N J Mitchell, R Evans, A Cheung, T L Kalber, R Bofinger, G O Fruhwirth, M Keppler, Z V F Wright, P R Barber, P Gordon, T de Koning, W Wulaningsih, K Sander, B Vojnovic, S Ameer-Beg, M Lythgoe, J N Arnold, E Årstad, F Festy, H C Hailes, A B Tabor and T Ng

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.522

LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells

H Xiong, Z Ni, J He, S Jiang, X Li, J He, W Gong, L Zheng, S Chen, B Li, N Zhang, X Lyu, G Huang, B Chen, Y Zhang and F He

Oncogene advance online publication, February 6, 2017; doi:10.1038/onc.2016.521

Top

January 30 2017

Original Articles

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells Open

G-A Franzetti, K Laud-Duval, W van der Ent, A Brisac, M Irondelle, S Aubert, U Dirksen, C Bouvier, G de Pinieux, E Snaar-Jagalska, P Chavrier and O Delattre

Oncogene advance online publication, January 30, 2017; doi:10.1038/onc.2016.498

The Cdc42/Rac1 regulator CdGAP is a novel E-cadherin transcriptional co-repressor with Zeb2 in breast cancer

Y He, J J Northey, A Pelletier, Z Kos, L Meunier, B Haibe-Kains, A-M Mes-Masson, J-F Côté, P M Siegel and N Lamarche-Vane

Oncogene advance online publication, January 30, 2017; doi:10.1038/onc.2016.492

Effective personalized therapy for breast cancer based on predictions of cell signaling pathway activation from gene expression analysis FREE

J-R Jhan and E R Andrechek

Oncogene advance online publication, January 30, 2017; doi:10.1038/onc.2016.503

Top

January 23 2017

Original Articles

HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment

A Guo, P Lu, J Lee, C Zhen, G Chiosis and Y L Wang

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.494

Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL Open

E Hasanov, G Chen, P Chowdhury, J Weldon, Z Ding, E Jonasch, S Sen, C L Walker and R Dere

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.495

The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma

C Hermanns, V Hampl, K Holzer, A Aigner, J Penkava, N Frank, D E Martin, K C Maier, N Waldburger, S Roessler, M Goppelt-Struebe, I Akrap, A Thavamani, S Singer, A Nordheim, T Gudermann and S Muehlich

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.496

RARRES2 functions as a tumor suppressor by promoting β-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma

Y Liu-Chittenden, M Jain, K Gaskins, S Wang, M J Merino, S Kotian, S Kumar Gara, S Davis, L Zhang and E Kebebew

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.497

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia Open

K H M Prange, A Mandoli, T Kuznetsova, S-Y Wang, A M Sotoca, A E Marneth, B A van der Reijden, H G Stunnenberg and J H A Martens

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.488

FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells Open

N Yang, C Wang, Z Wang, S Zona, S-X Lin, X Wang, M Yan, F-M Zheng, S-S Li, B Xu, L Bella, J-S Yong, E W-F Lam and Q Liu

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.490

The miR-487b-3p/GRM3/TGFβ signaling axis is an important regulator of colon cancer tumorigenesis

H Yi, L Geng, A Black, G Talmon, L Berim and J Wang

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.499

An integrated analysis identifies STAT4 as a key regulator of ovarian cancer metastasis

L Zhao, G Ji, X Le, Z Luo, C Wang, M Feng, L Xu, Y Zhang, W B Lau, B Lau, Y Yang, L Lei, H Yang, Y Xuan, Y Chen, X Deng, T Yi, S Yao, X Zhao, Y Wei and S Zhou

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.487

Short Communication

The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis

M Gueguinou, D Crottès, A Chantôme, R Rapetti-Mauss, M Potier-Cartereau, L Clarysse, A Girault, Y Fourbon, P Jézéquel, C Guérin-Charbonnel, G Fromont, P Martin, B Pellissier, R Schiappa, E Chamorey, O Mignen, A Uguen, F Borgese, C Vandier and O Soriani

Oncogene advance online publication, January 23, 2017; doi:10.1038/onc.2016.501

Top

January 16 2017

Review

Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches Open

C C Wong, Y Qian and J Yu

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.485

Original Articles

Utilizing somatic mutation data from numerous studies for cancer research: proof of concept and applications Open

D Amar, S Izraeli and R Shamir

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.489

Upregulation of RET induces perineurial invasion of pancreatic adenocarcinoma

M Amit, S Na'ara, L Leider-Trejo, Y Binenbaum, N Kulish, E Fridman, A Shabtai-Orbach, R J Wong and Z Gil

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.483

WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner Open

K Brown, P Yang, D Salvador, R Kulikauskas, H Ruohola-Baker, A M Robitaille, A J Chien, R T Moon and V Sherwood

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.450

PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma

J Delyon, A Servy, F Laugier, J André, N Ortonne, M Battistella, S Mourah, A Bensussan, C Lebbé and N Dumaz

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.469

A targetable HB-EGF–CITED4 axis controls oncogenesis in lung cancer

C-H Hsieh, Y-T Chou, M-H Kuo, H-P Tsai, J-L Chang and C-W Wu

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.465

BPGAP1 spatially integrates JNK/ERK signaling crosstalk in oncogenesis

T Jiang, C Q Pan and B C Low

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.466

Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition

H S Kim, M Jung, H N Kang, H Kim, C-W Park, S-M Kim, S J Shin, S H Kim, S G Kim, E K Kim, M R Yun, Z Zheng, K Y Chung, J Greenbowe, S M Ali, T-M Kim and B C Cho

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.486

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells

S Ros, J Flöter, I Kaymak, C Da Costa, A Houddane, S Dubuis, B Griffiths, R Mitter, S Walz, S Blake, A Behrens, K M Brindle, N Zamboni, M H Rider and A Schulze

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.477

Genome-wide analysis of p53-regulated transcription in Myc-driven lymphomas Open

C Tonelli, M J Morelli, A Sabò, A Verrecchia, L Rotta, T Capra, S Bianchi, S Campaner and B Amati

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.443

Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality Open

B W C Tse, M Volpert, E Ratther, N Stylianou, M Nouri, K McGowan, M L Lehman, S J McPherson, M Roshan-Moniri, M S Butler, J Caradec, C Y Gregory-Evans, J McGovern, R Das, M Takhar, N Erho, M Alshalafa, E Davicioni, E M Schaeffer, R B Jenkins, A E Ross, R J Karnes, R B Den, L Fazli, P A Gregory, M E Gleave, E D Williams, P S Rennie, R Buttyan, J H Gunter, L A Selth, P J Russell, C C Nelson and B G Hollier

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.482

Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma Open

C Worrall, N Suleymanova, C Crudden, I Trocoli Drakensjö, E Candrea, D Nedelcu, S-I Takahashi, L Girnita and A Girnita

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.472

IRF7 regulates the development of granulocytic myeloid-derived suppressor cells through S100A9 transrepression in cancer

Q Yang, X Li, H Chen, Y Cao, Q Xiao, Y He, J Wei and J Zhou

Oncogene advance online publication, January 16, 2017; doi:10.1038/onc.2016.448

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January 9 2017

Letter to the Editor

CIP2A confirms its prognostic value in triple-negative breast cancer

I Cristóbal, S Zazo, B Torrejón, M Pedregal, J Madoz-Gúrpide, A Lluch, P Eroles, A Rovira, J Albanell, J García-Foncillas and F Rojo

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.474

Review

Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance

J Vaquero, T H Nguyen Ho-Bouldoires, A Clapéron and L Fouassier

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.462

Original Articles

Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis

E Agarwal, C M Robb, L M Smith, M G Brattain, J Wang, J D Black and S Chowdhury

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.460

TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation

J Li, Y Xi, W Li, R L McCarthy, S A Stratton, W Zou, W Li, S Y Dent, A K Jain and M C Barton

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.453

Myc suppresses tumor invasion and cell migration by inhibiting JNK signaling

X Ma, J Huang, Y Tian, Y Chen, Y Yang, X Zhang, F Zhang and L Xue

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.463

The primacy of NF1 loss as the driver of tumorigenesis in neurofibromatosis type 1-associated plexiform neurofibromas

A Pemov, H Li, R Patidar, N F Hansen, S Sindiri, S W Hartley, J S Wei, A Elkahloun, S C Chandrasekharappa, J F Boland, S Bass, J C Mullikin, J Khan, B C Widemann, M R Wallace and D R Stewart

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.464

Analysis of DNA methylation in single circulating tumor cells

C F Pixberg, K Raba, F Müller, B Behrens, E Honisch, D Niederacher, H Neubauer, T Fehm, W Goering, W A Schulz, P Flohr, G Boysen, M Lambros, J S De Bono, W T Knoefel, C Sproll, N H Stoecklein and R P L Neves

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.480

KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth Open

M Riverso, V Montagnani and B Stecca

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.481

Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera

T Tsuruta-Kishino, J Koya, K Kataoka, K Narukawa, Y Sumitomo, H Kobayashi, T Sato and M Kurokawa

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.478

The Nogo-B receptor promotes Ras plasma membrane localization and activation

B Zhao, W Hu, S Kumar, P Gonyo, U Rana, Z Liu, B Wang, W Q Duong, Z Yang, C L Williams and Q R Miao

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.484

FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation

H Zhou, Y Liu, R Zhu, F Ding, Y Wan, Y Li and Z Liu

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.479

Short Communication

MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment

A Ugale, P Säwén, M Dudenhöffer-Pfeifer, M Wahlestedt, G L Norddahl and D Bryder

Oncogene advance online publication, January 9, 2017; doi:10.1038/onc.2016.470

Top

December 19 2016

Review

Rho GTPases: Anti- or pro-neoplastic targets?

I Zandvakili, Y Lin, J C Morris and Y Zheng

Oncogene advance online publication, December 19, 2016; doi:10.1038/onc.2016.473

Original Articles

PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer

D A Modi, R D Tagare, S Karthikeyan, A Russo, M Dean, D A Davis, D D Lantvit and J E Burdette

Oncogene advance online publication, December 19, 2016; doi:10.1038/onc.2016.455

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia Open

E J Pomeroy, L A Lee, R D W Lee, D K Schirm, N A Temiz, J Ma, T A Gruber, E Diaz-Flores, B S Moriarity, J R Downing, K M Shannon, D A Largaespada and C E Eckfeldt

Oncogene advance online publication, December 19, 2016; doi:10.1038/onc.2016.471

Chronic inflammation initiates multiple forms of K-Ras-independent mouse pancreatic cancer in the absence of TP53 Open

A K Swidnicka-Siergiejko, S B Gomez-Chou, Z Cruz-Monserrate, D Deng, Y Liu, H Huang, B Ji, N Azizian, J Daniluk, W Lu, H Wang, A Maitra and C D Logsdon

Oncogene advance online publication, December 19, 2016; doi:10.1038/onc.2016.461

EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis Open

S-A Wang, Y-C Wang, Y-P Chuang, Y-H Huang, W-C Su, W-C Chang and J-J Hung

Oncogene advance online publication, December 19, 2016; doi:10.1038/onc.2016.445

Cancer-FOXP3 directly activated CCL5 to recruit FOXP3+Treg cells in pancreatic ductal adenocarcinoma Open

X Wang, M Lang, T Zhao, X Feng, C Zheng, C Huang, J Hao, J Dong, L Luo, X Li, C Lan, W Yu, M Yu, S Yang and H Ren

Oncogene advance online publication, December 19, 2016; doi:10.1038/onc.2016.458

miR-19a promotes colitis-associated colorectal cancer by regulating tumor necrosis factor alpha-induced protein 3-NF-κB feedback loops

T Wang, X Xu, Q Xu, J Ren, S Shen, C Fan and Y Hou

Oncogene advance online publication, December 19, 2016; doi:10.1038/onc.2016.468

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December 12 2016

Original Articles

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination Open

E Crosas-Molist, E Bertran, I Rodriguez-Hernandez, C Herraiz, G Cantelli, À Fabra, V Sanz-Moreno and I Fabregat

Oncogene advance online publication, December 12, 2016; doi:10.1038/onc.2016.454

ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation Open

L Dumartin, W Alrawashdeh, S M Trabulo, T P Radon, K Steiger, R M Feakins, M P di Magliano, C Heeschen, I Esposito, N R Lemoine and T Crnogorac-Jurcevic

Oncogene advance online publication, December 12, 2016; doi:10.1038/onc.2016.459

Emergent role of the fractalkine axis in dissemination of peritoneal metastasis from epithelial ovarian carcinoma

H Gurler Main, J Xie, G G Muralidhar, O Elfituri, H Xu, A A Kajdacsy-Balla and M V Barbolina

Oncogene advance online publication, December 12, 2016; doi:10.1038/onc.2016.456

Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma

H Janakiraman, R P House, S Talwar, S M Courtney, E S Hazard, G Hardiman, S Mehrotra, P H Howe, V Gangaraju and V Palanisamy

Oncogene advance online publication, December 12, 2016; doi:10.1038/onc.2016.451

Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival

C Kerr, H Szmacinski, M L Fisher, B Nance, J R Lakowicz, A Akbar, J W Keillor, T Lok Wong, R Godoy-Ruiz, E A Toth, D J Weber and R L Eckert

Oncogene advance online publication, December 12, 2016; doi:10.1038/onc.2016.452

The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis

M Sarkar, V Khare and M K Ghosh

Oncogene advance online publication, December 12, 2016; doi:10.1038/onc.2016.449

Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic

F Volpin, J Casaos, J Sesen, A Mangraviti, J Choi, N Gorelick, J Frikeche, T Lott, R Felder, S J Scotland, T S K Eisinger-Mathason, H Brem, B Tyler and N Skuli

Oncogene advance online publication, December 12, 2016; doi:10.1038/onc.2016.457

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November 28 2016

Short Communication

Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma

A Miller, L McLeod, S Alhayyani, A Szczepny, D N Watkins, W Chen, P Enriori, W Ferlin, S Ruwanpura and B J Jenkins

Oncogene advance online publication, November 28, 2016; doi:10.1038/onc.2016.437

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November 21 2016

Original Article

Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling

X Tang, C-K Ding, J Wu, J Sjol, S Wardell, I Spasojevic, D George, D P McDonnell, D S Hsu, J T Chang and J-T Chi

Oncogene advance online publication, November 21, 2016; doi:10.1038/onc.2016.394

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November 7 2016

Original Article

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells Open

J F van Lidth de Jeude, B J Meijer, M C B Wielenga, C N Spaan, B Baan, S L Rosekrans, S Meisner, Y H Shen, A S Lee, J C Paton, A W Paton, V Muncan, G R van den Brink and J Heijmans

Oncogene advance online publication, November 7, 2016; doi:10.1038/onc.2016.326

Top

October 17 2016

Original Articles

Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells Open

F Faião-Flores, D K Alves-Fernandes, P C Pennacchi, S Sandri, A L S A Vicente, C Scapulatempo-Neto, V L Vazquez, R M Reis, J Chauhan, C R Goding, K S Smalley and S S Maria-Engler

Oncogene advance online publication, October 17, 2016; doi:10.1038/onc.2016.348

MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation FREE

D-L Qi and D Cobrinik

Oncogene advance online publication, October 17, 2016; doi:10.1038/onc.2016.350

Top

October 10 2016

Original Articles

Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora Open

W Bruinsma, M Aprelia, I García-Santisteban, J Kool, Y J Xu and R H Medema

Oncogene advance online publication, October 10, 2016; doi:10.1038/onc.2016.347

Physical interaction of estrogen receptor with MnSOD: implication in mitochondrial O2 .− upregulation and mTORC2 potentiation in estrogen-responsive breast cancer cells FREE

M-U-D Lone, K S Baghel, R K Kanchan, R Shrivastava, S A Malik, B N Tewari, C Tripathi, M P S Negi, V K Garg, M Sharma, M L B Bhatt and S Bhadauria

Oncogene advance online publication, October 10, 2016; doi:10.1038/onc.2016.346

Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer FREE

R Mimoto, Y Imawari, S Hirooka, H Takeyama and K Yoshida

Oncogene advance online publication, October 10, 2016; doi:10.1038/onc.2016.349

HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer FREE

N Stojanovic, Z Hassan, M Wirth, P Wenzel, M Beyer, C Schäfer, P Brand, A Kroemer, R H Stauber, R M Schmid, A Arlt, A Sellmer, S Mahboobi, R Rad, M Reichert, D Saur, O H Krämer and G Schneider

Oncogene advance online publication, October 10, 2016; doi:10.1038/onc.2016.344

Top

October 3 2016

Original Articles

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium Open

C S Daly, P Shaw, L D Ordonez, G T Williams, J Quist, A Grigoriadis, J H Van Es, H Clevers, A R Clarke and K R Reed

Oncogene advance online publication, October 3, 2016; doi:10.1038/onc.2016.342

Transducin (β)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway Open

Q Zhou, X Wang, Z Yu, X Wu, X Chen, J Li, Z Zhu, B Liu and L Su

Oncogene advance online publication, October 3, 2016; doi:10.1038/onc.2016.352

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September 26 2016

Original Articles

The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion Open

S R Frank, C P Köllmann, J F van Lidth de Jeude, J R Thiagarajah, L H Engelholm, M Frödin and S H Hansen

Oncogene advance online publication, September 26, 2016; doi:10.1038/onc.2016.345

The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3 FREE

Z Li, B Bridges, J Olson and S A Weinman

Oncogene advance online publication, September 26, 2016; doi:10.1038/onc.2016.359

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells FREE

K E Richards, A E Zeleniak, M L Fishel, J Wu, L E Littlepage and R Hill

Oncogene advance online publication, September 26, 2016; doi:10.1038/onc.2016.353

Top

September 19 2016

Original Article

FERMT1 mediates epithelial–mesenchymal transition to promote colon cancer metastasis via modulation of β-catenin transcriptional activity FREE

C-C Liu, D-L Cai, F Sun, Z-H Wu, B Yue, S-L Zhao, X-S Wu, M Zhang, X-W Zhu, Z-H Peng and D-W Yan

Oncogene advance online publication, September 19, 2016; doi:10.1038/onc.2016.339

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September 5 2016

Review

Epigenetic therapies by targeting aberrant histone methylome in AML: molecular mechanisms, current preclinical and clinical development Open

C T Tsai and C W E So

Oncogene advance online publication, September 5, 2016; doi:10.1038/onc.2016.315

Top

February 2 2015

Original Article

The breast cancer susceptibility FGFR2 provides an alternate mode of HER2 activation

W Wei, W Liu, S Serra, S L Asa and S Ezzat

Oncogene advance online publication, February 2, 2015; doi:10.1038/onc.2014.440

Top

June 9 2014

Original Article

IL-6 secreted by cancer-associated fibroblasts induces tamoxifen resistance in luminal breast cancer Open

X Sun, Y Mao, J Wang, L Zu, M Hao, G Cheng, Q Qu, D Cui, E T Keller, X Chen, K Shen and J Wang

Oncogene advance online publication, June 9, 2014; doi:10.1038/onc.2014.158

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