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Genomic instability in pre-neoplastic colonic lesions

Oncogene volume 32, pages 5331–5332 (2013)Cite this article

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Abstract

Genomic instability is a characteristic of most cancers and it is argued that genomic instability is a driving force for tumorigenesis. Data herein demonstrate that genomic instability, as evidenced by microsatellite instability (MSI) and promoter methylation of DNA mismatch repair genes, is common in individual glands of pre-malignant colorectal lesions and raises interesting questions about the role of MSI in the development of colorectal carcinoma.

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Authors and Affiliations

  1. Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK

    J A Shaw

  2. Department of Surgery, Center for Evolution and Cancer, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA

    T A Graham

  3. Division of Cancer, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK

    J Stebbing

Authors
  1. J A Shaw
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  2. T A Graham
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  3. J Stebbing
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Correspondence to J Stebbing.

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The authors declare no conflict of interest.

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Shaw, J., Graham, T. & Stebbing, J. Genomic instability in pre-neoplastic colonic lesions. Oncogene 32, 5331–5332 (2013). https://doi.org/10.1038/onc.2013.21

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  • DOI: https://doi.org/10.1038/onc.2013.21

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