1. ¹Department of Pathology, University of California at San Diego, La Jolla, CA, USA
2. ²Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA

Correspondence: Professor R Klemke, Department of Pathology and Moores Cancer Center, University of California at San Diego, 9500 Gilman Drive, MC0612, La Jolla, CA 92093, USA. E-mail: rklemke@ucsd.edu

Received 29 February 2008; Accepted 4 March 2008; Published online 31 March 2008.

Abstract

Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects of different human cancers including lymphoblastic T-cell leukemia, pancreatic cancer, melanoma and rhabdomyosarcoma. These models are already being utilized by academia and industry to search for genetic and chemical modifiers of cancer with success. The attention has been further stimulated by the amenability of zebrafish to pharmacological testing and the superior imaging properties of fish tissues that allow visualization of cancer progression and angiogenesis in live animals. This review summarizes the current zebrafish models of cancer and discusses their utility in human cancer research and future directions in the field.