Oncogene

FIGURE 3

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Cigarette smoke induces demethylation of prometastatic oncogene synuclein-bold italic gamma in lung cancer cells by downregulation of DNMT3B

H Liu, Y Zhou, S E Boggs, S A Belinsky and J Liu

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Figure 3.

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Effects of CSE on the methylation status of TSGs and prometastatic oncogenes. A549 cells were untreated or treated with 5% CSE for 3 or 6 days. Genomic DNA was isolated and modified by sodium bisulfite. MNMSP was conducted as described in the 'Materials and Methods' section. M, methylated PCR product; U, unmethylated PCR products.

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