Original Article

Oncogene (2007) 26, 1517–1521. doi:10.1038/sj.onc.1209952; published online 4 September 2006

The p53 knowledgebase: an integrated information resource for p53 research

Y P Lim1, T T Lim1,3, Y L Chan1,3, A C M Song1,3, B H Yeo1,3, B Vojtesek2, D Coomber2, G Rajagopal1 and D Lane2

  1. 1Bioinformatics Institute, Matrix, Singapore, Singapore
  2. 2Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore

Correspondence: Professor Sir David Lane, Institute of Molecular and Cell Biology, 61 Biopolis Street, Proteos, Singapore 138673, Singapore. E-mail: d.p.lane@imcb.a-star.edu.sg; Dr G Rajagopal, Bioinformatics Institute, 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore. E-mail: guna@bii.a-star.edu.sg

3These authors contributed equally to this work.

Received 16 May 2006; Accepted 27 July 2006; Published online 4 September 2006.

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Abstract

The p53 tumor suppressor protein plays a central role in maintaining genomic integrity by occupying a nodal point in the DNA damage control pathway. Here it integrates a wide variety of signals, responding in one of several ways, that is, cell cycle arrest, senescence or programmed cell death (apoptosis). Mutations in the tumor suppressor gene tp53, which affects the key transcriptional regulatory processes in cell growth and death, occur frequently in cancer and helps explain why p53 has been called the guardian of the genome. There is a vast body of published knowledge on all aspects of p53's role in cancer. To facilitate research, it would be helpful if this information could be collected, curated and updated in a format that is easily accessible to the user community. To this end, we initiated the p53 knowledgebase project (http://p53.bii.a-star.edu.sg). The p53 knowledgebase is a user-friendly web portal incorporating visualization and analysis tools that integrates information from the published literature with other manually curated information to facilitate knowledge discovery. This includes curated information on sequence, structural, mutation, polymorphisms, protein–protein interactions, transcription factors, transcriptional targets, antibodies and post-translational modifications that involve p53. The goal is to collect and maintain all relevant data on p53 and present it in an easily accessible format that will be useful to researchers in the field.

Keywords:

database, p53, web portal

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