1. ¹Department of Human Pathology and Oncology, University of Siena, Siena, Italy
2. ²Sbarro Institute for Cancer Research & Molecular Medicine, Temple University, Philadelphia, PA 19122, USA

Correspondence: Dr L Leoncini, Department of Human Pathology and Oncology, University of Siena, Siena 53100, Italy. E-mail: leoncinil@unisi.it

Abstract

It appears more and more clear that retinoblastoma (RB) family of proteins represents key molecules in tumour suppression. This family consists of pRb/p105, p107 and pRb2/p130, which participate in a gene regulatory network that governs the cellular response to antimitogenic signals, and whose deregulation constitutes one of the hallmarks of cancer. Irrespective of their structural and biochemical similarities, RB proteins carry out different functional tasks. The expression of RB gene family in the reactive lymphoid tissues again confirms the different role of each member in cell cycle control and differentiation of normal cells. These different functional properties appear to be maintained in tumours lymphoid tissues, where alterations of the RB/p105 gene appear to be relatively rare. In this review, we will summarize the current knowledge about the role of the RB proteins in reactive and neoplastic lymphoid tissue.