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Mitochondrial factors with dual roles in death and survival

Oncogene volume 25, pages 4697–4705 (2006)Cite this article

Abstract

At least in mammals, we have some understanding of how caspases facilitate mitochondria-mediated cell death, but the biochemical mechanisms by which other factors promote or inhibit programmed cell death are not understood. Moreover, most of these factors are only studied after treating cells with a death stimulus. A growing body of new evidence suggests that cell death regulators also have ‘day jobs’ in healthy cells. Even caspases, mitochondrial fission proteins and pro-death Bcl-2 family proteins appear to have normal cellular functions that promote cell survival. Here, we review some of the supporting evidence and stretch beyond the evidence to seek an understanding of the remaining questions.

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA

    W-C Cheng, S B Berman, F Pineda & J M Hardwick

  2. Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA

    S B Berman & J M Hardwick

  3. Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA

    S B Berman

  4. Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA

    I Ivanovska, Y Chen & J M Hardwick

  5. Department of Endocrinology, Yale University, New Haven, CT, USA

    E A Jonas

  6. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA

    S J Lee

  7. Department of Pharmacology, Yale University, New Haven, CT, USA

    L K Kaczmarek

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Cheng, WC., Berman, S., Ivanovska, I. et al. Mitochondrial factors with dual roles in death and survival. Oncogene 25, 4697–4705 (2006). https://doi.org/10.1038/sj.onc.1209596

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