Oncogene

TABLE 2

FROM:

Glycolysis inhibition for anticancer treatment

H Pelicano, D S Martin, R-H Xu and P Huang

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Table 2. Glycolytic inhibitors and compounds that modulate glycolytic metabolism

Compound status Mechanisms of action Drug development
2-DeoxyglucoseInhibits phosphorylation of glucose by hexokinaseClinical trials (I/II)
   
LonidamineInhibits glycolysis and mitochondrial respirationClinical trials (II/III)
 Inhibits HK; disassociating HK from mitochondria 
   
3-BromopyruvateInhibits HK; acts as an alkylating agentPre-clinical
   
ImatinibInhibit Bcr-Abl tyrosine kinase; causes a decrease in HK and G6PD activityApproved for clinical use
   
OxythiamineSuppresses PPP by inhibiting transketolase; inhibits pyruvate dehydrogenasePre-clinical

 Abbreviations: HK, hexokinase; G6PG, glucose-6-phosphate dehydrogenase; PPP, pentose phosphate pathway.

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