Oncogene

FIGURE 5

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Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM

Hiroyuki Tagawa, Sivasundaram Karnan, Ritsuro Suzuki, Keitaro Matsuo, Xiaohua Zhang, Akinobu Ota, Yasuo Morishima, Shigeo Nakamura and Masao Seto

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Figure 5.

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Southern blot and FISH analysis of a patient sample (G468). (a) Southern blot analysis. Lane 1: human placenta. Lanes 2, 3, 5: Patient samples without 2q13 deletion. Lane 4: G468 showing 2q13 loss by array CGH (see Figure 3). Lane 6: Jeko-1 cell line showing homozygous deletion at BIM locus. Probe 2 that contain BIM exon was used in this experiment. (b) Dual-color FISH analysis with probes A and B of G468. Probe A: BAC438K19; probe B: BAC368A17. Probe B is 1.55 Mb telomeric to probe A, and BAC438K19 contains the BIM gene. Interphase chromosomes have two pairs of red signals (probe B, red), and one pair of green signals (probe A, green), indicating heterozygous loss of probe A

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